Giger U, Gelens C J, Callan M B, Oakley D A
Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104-6010, USA.
J Am Vet Med Assoc. 1995 May 1;206(9):1358-62.
An acute hemolytic transfusion reaction resulting from dog erythrocyte antigen (DEA) 1.1 incompatibility developed in a dog previously sensitized to DEA 1.1 by a transfusion 3 years earlier. The dog developed fever, pigmenturia, and lethargy, and its PCV did not rise as expected. The donor blood was type DEA 1.1 positive, whereas the recipient's blood was type DEA 1.1, DEA 1.2, and DEA 7 negative. A major crossmatch was later found to be strongly incompatible. Studies of the recipient's plasma revealed a specific anti-DEA 1.1 alloantibody of the IgG class with high hemolysin and agglutinin activity. Such acute hemolytic transfusion reactions can be avoided by crossmatching previously transfused dogs and by using dogs that are type DEA 1.1 negative (and preferably also type DEA 1.2 and DEA 7 negative) as blood donors.
一只狗三年前曾因输血对犬红细胞抗原（DEA）1.1致敏，此次因DEA 1.1不相容引发了急性溶血性输血反应。这只狗出现发热、血红蛋白尿和嗜睡症状，其红细胞压积未如预期上升。供血犬的血型为DEA 1.1阳性，而受血犬的血型为DEA 1.1、DEA 1.2和DEA 7阴性。后来发现主侧交叉配血严重不相容。对受血犬血浆的研究显示，存在一种IgG类特异性抗DEA 1.1同种抗体，具有高溶血素和凝集素活性。通过对曾接受输血的犬进行交叉配血，并使用DEA 1.1阴性（最好也是DEA 1.2和DEA 7阴性）的犬作为供血犬，可避免此类急性溶血性输血反应。
