Poehlman E T, Gardner A W, Goran M I, Arciero P J, Toth M J, Ades P A, Calles-Escandon J
Department of Medicine, Baltimore Veterans Affairs Medical Center, University of Maryland 21201, USA.
J Appl Physiol (1985). 1995 Mar;78(3):802-6. doi: 10.1152/jappl.1995.78.3.802.
It was hypothesized that an increase in total and central body fatness is related to higher sympathetic nervous system activity (SNSA) in older men. Resting SNSA was measured from norepinephrine (NE) kinetics in 69 younger (18-36 yr) and 69 healthy older men (55-80 yr). Body fat distribution was estimated from the waist circumference, body composition from underwater weighing, peak oxygen consumption from a treadmill test to exhaustion, and dietary intake from food diaries. Plasma NE concentrations were 41% higher (P < 0.001) in older men due to a 27% increase (P < 0.001) in NE appearance rate and a tendency for a lower NE clearance rate (P = 0.08). NE appearance rate was higher in individuals of both age groups who exhibited a greater waist circumference and body fatness (range of r values 0.49-0.69; P < 0.01). The waist circumference, and not age, was the strongest predictor of the increase in NE appearance rate in older men. Statistically controlling for the waist circumference or body fatness diminished age-related differences in NE concentrations and in NE appearance rate. These findings suggest that an accumulation of total and central body fat is associated with higher levels of SNSA in older males.
研究假设，老年男性总体及中心性肥胖的增加与较高的交感神经系统活性（SNSA）有关。通过测定69名年轻男性（18 - 36岁）和69名健康老年男性（55 - 80岁）去甲肾上腺素（NE）动力学来评估静息SNSA。通过腰围评估体脂分布，通过水下称重评估身体成分，通过跑步机测试至 exhaustion来评估峰值耗氧量，并通过食物日记评估饮食摄入量。老年男性血浆NE浓度高出41%（P < 0.001），原因是NE出现率增加27%（P < 0.001），且NE清除率有降低趋势（P = 0.08）。在两个年龄组中，腰围和体脂较高的个体NE出现率更高（r值范围为0.49 - 0.69；P < 0.01）。腰围而非年龄是老年男性NE出现率增加的最强预测因素。对腰围或体脂进行统计学控制可减少与年龄相关的NE浓度及NE出现率差异。这些发现表明，总体及中心性体脂的积累与老年男性较高水平的SNSA相关。 （注：原文中“treadmill test to exhaustion”这里“exhaustion”可能表述有误，推测可能是“treadmill test to exhaustion point”之类意思，按原文翻译了，但不太明确此处准确意思）
