Kenney M J, Barney C C, Hirai T, Gisolfi C V
Department of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan 66506, USA.
J Appl Physiol (1985). 1995 Mar;78(3):881-9. doi: 10.1152/jappl.1995.78.3.881.
The aim of the present study was to characterize the sympathetic nerve responses to hyperthermia in chloralose-anesthetized rats. Discharges were recorded from the renal, lumbar, and splanchnic sympathetic nerves. Mean arterial pressure, heart rate, and sympathetic nerve discharge (SND) were recorded continuously during progressive increases in core body temperature (Tc) from 38.0 to 41.0 degrees C. The following observations were made: 1) significant increases in renal, lumbar, and splanchnic SND were observed during hyperthermia; 2) autospectral analysis of renal and lumbar SND revealed that the frequency distribution of SND can be altered during progressive increases in Tc; and 3) increases in splanchnic SND to acute heating were similar in baroreceptor-innervated and -denervated rats. We conclude that 1) hyperthermia is a potent stimulus to the sympathetic nervous system and increases the activity in three sympathetic nerves that innervate different regional arterial beds, 2) acute heating influences the neural circuits involved in generating SND as evidenced by changes in the basic pattern of renal and lumbar SND, and 3) the increase in splanchnic SND during hyperthermia is not opposed by the arterial and cardiopulmonary baroreceptors.
本研究的目的是描述水合氯醛麻醉大鼠对热疗的交感神经反应。记录肾、腰和内脏交感神经的放电情况。在核心体温（Tc）从38.0℃逐渐升高至41.0℃的过程中，持续记录平均动脉压、心率和交感神经放电（SND）。得到以下观察结果：1）热疗期间观察到肾、腰和内脏SND显著增加；2）对肾和腰SND的自谱分析显示，在Tc逐渐升高过程中SND的频率分布会发生改变；3）在有压力感受器支配和去神经支配的大鼠中，急性加热引起的内脏SND增加相似。我们得出以下结论：1）热疗是交感神经系统的一种有效刺激，可增加支配不同区域动脉床的三条交感神经的活动；2）急性加热影响参与产生SND的神经回路，肾和腰SND基本模式的变化证明了这一点；3）热疗期间内脏SND的增加不受动脉和心肺压力感受器的拮抗。
