Johnson J M, Pérgola P E, Liao F K, Kellogg D L, Crandall C G
Department of Physiology, University of Texas Health Science Center at San Antonio 78284, USA.
J Appl Physiol (1985). 1995 Mar;78(3):948-54. doi: 10.1152/jappl.1995.78.3.948.
To test for an active vasodilator system in human hand and finger skin, seven subjects had a small area of dorsal hand, palm, or dorsal finger pretreated with bretylium (BT) to block adrenergic vasoconstriction. Skin blood flow was monitored at a BT-treated site, a comparable untreated site, and the forearm by laser-Doppler flowmetry. Cutaneous vascular conductance (CVC) was evaluated from the ratio of blood flow to arterial pressure. Body cooling, to evaluate vasoconstrictor system blockade, caused CVC at untreated sites of forearm, palm, dorsal hand, and dorsal finger to fall by 45 +/- 4, 85 +/- 5, 51 +/- 9, and 63 +/- 7%, respectively (all P < 0.05). At BT-treated sites of palm, dorsal hand, and dorsal finger, reductions in CVC were only 13 +/- 3, 2 +/- 18, and 13 +/- 4%, respectively (dorsal hand not significant, others P < 0.05). With body heating, increases in CVC at untreated sites of forearm, palm, dorsal hand, and dorsal finger were 881 +/- 165, 779 +/- 368, 423 +/- 115, and 1,430 +/- 716%, respectively (all P < 0.05). At BT-treated sites of palm, dorsal hand, and dorsal finger, increases were 35 +/- 15, 342 +/- 107, and 343 +/- 34%, respectively (palm not significant, others P < 0.05). Increased CVC at the palm began after 1.2 +/- 0.2 min of heating, significantly earlier than forearm (11.8 +/- 2.5 min), dorsal hand (16.4 +/- 3.4 min), or dorsal finger (15.6 +/- 3.6 min), which did not differ significantly from one another.(ABSTRACT TRUNCATED AT 250 WORDS)
为检测人体手部和手指皮肤中是否存在活跃的血管舒张系统，七名受试者的手背、手掌或手指背的一小块区域预先用溴苄铵（BT）进行处理，以阻断肾上腺素能血管收缩。通过激光多普勒血流仪在前臂、一个经BT处理的部位、一个未处理的对照部位监测皮肤血流。根据血流与动脉压的比值评估皮肤血管传导率（CVC）。为评估血管收缩系统阻断情况，对身体进行降温，结果显示，在前臂、手掌、手背和手指背的未处理部位，CVC分别下降了45±4%、85±5%、51±9%和63±7%（均P<0.05）。在手掌、手背和手指背的BT处理部位，CVC的下降幅度分别仅为13±3%、2±18%和13±4%（手背差异不显著，其他部位P<0.05）。身体升温时，在前臂、手掌、手背和手指背的未处理部位，CVC的增加幅度分别为881±165%、779±368%、423±115%和1430±716%（均P<0.05）。在手掌、手背和手指背的BT处理部位，CVC的增加幅度分别为35±15%、342±107%和343±34%（手掌差异不显著，其他部位P<0.05）。手掌部位在加热1.2±0.2分钟后CVC开始增加，明显早于前臂（11.8±2.5分钟）、手背（16.4±3.4分钟）或手指背（15.6±3.6分钟），而后三者之间差异不显著。（摘要截取自250字）
