Sakugawa H, Nakasone H, Shokita H, Nakayoshi T, Kinjo F, Saito A, Yamashiro A, Miyagi Y
First Department of Internal Medicine, Faculty of Medicine, School of Medicine, University Hospital, University of the Ryukyus, Okinawa, Japan.
J Med Virol. 1995 Mar;45(3):312-5. doi: 10.1002/jmv.1890450313.
A seroepidemiological study on hepatitis delta virus (HDV) infection was conducted in the Okinawan islands, the area of Japan where hepatitis B virus infection is most prevalent. The subjects of this study included 116 asymptomatic hepatitis B surface antigen (HBsAg) carriers, 48 patients with chronic hepatitis (CH), 19 with liver cirrhosis (LC), and 11 with hepatocellular carcinoma (HCC). Among the 194 serum samples examined, a total of 10 (5.2%) were anti-HDV seropositive. Anti-HDV was detected in 2 (1.7%) of the 116 asymptomatic HBsAg carriers, in 3 (6.3%) of the 48 patients with CH, and in 5 (26.3%) of the 19 with LC. However, none of the patients with HCC had detectable anti-HDV. Eight of the 10 were born in the Miyako island group and the remaining 2 on the main island of Okinawa. Since the subjects included 34 individuals who were living and/or born in the Miyako islands, the positive rate of anti-HDV in the islands was 23.5%. This study demonstrates the existence of an endemic area of HDV infection in Japan.
在日本乙肝病毒感染最为普遍的地区冲绳岛，开展了一项关于丁型肝炎病毒（HDV）感染的血清流行病学研究。该研究的对象包括116名无症状乙肝表面抗原（HBsAg）携带者、48名慢性肝炎（CH）患者、19名肝硬化（LC）患者以及11名肝细胞癌（HCC）患者。在所检测的194份血清样本中，共有10份（5.2%）抗HDV血清学检测呈阳性。在116名无症状HBsAg携带者中有2份（1.7%）检测到抗HDV，在48名CH患者中有3份（6.3%）检测到抗HDV，在19名LC患者中有5份（26.3%）检测到抗HDV。然而，所有HCC患者均未检测到可检测水平的抗HDV。10名抗HDV阳性者中有8人出生于宫古岛组，其余2人出生于冲绳主岛。由于研究对象包括34名在宫古岛生活和/或出生的个体，该岛抗HDV阳性率为23.5%。本研究证实了日本存在HDV感染的地方性流行区。
