Fayer R, Graczyk T K, Cranfield M R
Parasite Immunobiology Laboratory, Agricultural Research Service, Beltsville, Maryland 20705, USA.
J Parasitol. 1995 Jun;81(3):482-4.
Oral inoculations of 9 litter-groups of 3 5-day-old suckling BALB/c mouse pups (Mus musculus) with 6.7 x 10(3) to 1.2 x 10(5) per pup of viable, Cryptosporidium serpentis oocysts from snakes resulted in no transmission. Mice showed normal development; the litter-group weight gain was not altered significantly (P > 0.05) relative to the total number of C. serpentis oocysts inoculated or to the initial group weight (P > 0.05). Histological sections of stomach, duodenum, jejunum, ileum, cecum, and colon 4 days postinoculation did not contain life-cycle stages of Cryptosporidium in any inoculated mice. Because these neonatal, C. parvum-susceptible BALB/c mice were resistant to infection it is unlikely that C. serpentis transmission to the snakes "via infected prey" results when captive snakes are maintained on a diet of BALB/c mice.
用来自蛇的每只6.7×10³至1.2×10⁵个活的微小隐孢子虫卵囊对9窝35日龄的BALB/c乳鼠（小家鼠）进行口服接种，未导致传播。小鼠发育正常；相对于接种的微小隐孢子虫卵囊总数或初始组体重，窝组体重增加没有显著变化（P>0.05）。接种后4天，任何接种小鼠的胃、十二指肠、空肠、回肠、盲肠和结肠的组织学切片均未发现隐孢子虫的生命周期阶段。由于这些对微小隐孢子虫易感的新生BALB/c小鼠对感染具有抗性，因此当圈养蛇以BALB/c小鼠为食时，微小隐孢子虫不太可能“通过受感染的猎物”传播给蛇。
