Hirabayashi Y, Mitsuhata H, Shimizu R, Saitoh K, Fukuda H, Saitoh J, Horiguchi Y, Togashi H, Inoue S, Hotta K
Department of Anesthesiology, Jichi Medical School, Tochigi.
Masui. 1995 Apr;44(4):493-8.
We examined the analgesic efficacy and side effects of continuous epidural infusion with buprenorphine in 340 surgical patients. The patients received epidural injection of 0.1 mg of buprenorphine in 8 ml of 0.25% bupivacaine immediately after surgery. The patients who underwent thoracotomy or intraabdominal surgery were subsequently infused with buprenorphine 15 micrograms in 1 ml of 0.25% buprenorphine at a rate of 1 ml.h-1 for 48 h. In the other kinds of surgery, patients were infused with buprenorphine 8 micrograms in 1 ml of 0.25% buprenorphine at a rate of 1 ml.h-1 for 48 h. The patients who did not need additional narcotics were 68% and 83% on the postoperative day 1 and 2, respectively. Visual analogue scale (VAS) was 22 +/- 2 mm at rest and 43 +/- 2 mm at movement on the postoperative day 1. Corresponding values on the postoperative day 2 were 16 +/- 2 mm and 37 +/- 2 mm, respectively. Nausea and vomiting were found in 12.4% of the patients.
我们研究了340例外科手术患者连续硬膜外输注丁丙诺啡的镇痛效果及副作用。患者在术后立即接受硬膜外注射8毫升含0.1毫克丁丙诺啡的0.25%布比卡因。接受开胸手术或腹部手术的患者随后以每小时1毫升的速度输注1毫升含15微克丁丙诺啡的0.25%布比卡因，持续48小时。在其他类型的手术中，患者以每小时1毫升的速度输注1毫升含8微克丁丙诺啡的0.25%布比卡因，持续48小时。术后第1天和第2天分别有68%和83%的患者不需要额外使用麻醉剂。术后第1天静息时视觉模拟评分（VAS）为22±2毫米，活动时为43±2毫米。术后第2天相应值分别为16±2毫米和37±2毫米。12.4%的患者出现恶心和呕吐。
