Lukhanina E P, Kolomiets B P
Department of the Physiology of the Cerebral Cortex and Subcortical Structures, A. A. Bogomolets Institute of Physiology, Academy of Sciences of Ukraine, Kiev.
Neurosci Behav Physiol. 1995 Jan-Feb;25(1):58-62. doi: 10.1007/BF02359251.
The activity of neurons of the reticular portion of the substantia nigra before and after the microinjection of haloperidol (25 micrograms/5 microliters) into the head of the caudate nucleus on the ipsilateral side was investigated under chronic experimental conditions in cats, using the extracellular microelectrode pickup technique. A significant (p < 0.05) increase, from 34 to 61%, of neurons with the burst type of spontaneous activity was established after the injection of haloperidol. A significant increase in the ratio of the number of excitatory responses to inhibitory responses, from 0.04 to 0.4, was identified among the reactions associated with saccadic eye movements following the microinjection of haloperidol. The number of orienting saccades in response to the visual stimulus decreased against this background from 58 to 37%. The identified changes are regarded as a result of the disinhibition of GABAergic neurons of the reticular portion of the substantia nigra under the influence of the blockade of D2 dopamine receptors of the neostriatum.
在慢性实验条件下，对猫采用细胞外微电极记录技术，研究向同侧尾状核头部微量注射氟哌啶醇（25微克/5微升）前后黑质网状部神经元的活动。注射氟哌啶醇后，自发活动为爆发型的神经元数量显著增加（p<0.05），从34%增至61%。微量注射氟哌啶醇后，与眼球扫视运动相关的反应中，兴奋性反应与抑制性反应的数量比显著增加，从0.04增至0.4。在此背景下，对视觉刺激做出反应的定向扫视次数从58次降至37次。所发现的这些变化被认为是新纹状体D2多巴胺受体被阻断后，黑质网状部GABA能神经元去抑制的结果。
