Shapovalova K B
Laboratory of Physiology of Higher Nervous Activity, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, Saint Petersburg.
Neurosci Behav Physiol. 1995 Jan-Feb;25(1):71-80. doi: 10.1007/BF02359253.
Data have been obtained in chronic experiments on 34 dogs, based on an instrumental defense reflex model associated with the maintenance of a specific posture, which suggest that activation of the cholinergic system of the neostriatum leads to a large number of changes in both the sensory and the motor spheres. The influences on motor behavior, observed mainly through effects on the cholinergic system of the contralateral caudate nucleus, reside in the intensification of the tonic constituent of movement, in inhibition of the phasic component of movement, and restriction of locomotor activity, all the way up to complete shutdown. The influences on sensory mechanisms, observed both through ipsi- and contralateral effects on the cholinergic system of the neostriatum, reside in an improvement of the differentiation of significant signals and are evidently through inhibition of the nonspecific afferent stream. Data are presented on the important role of the cholinoreactive systems of the CM-Pf complex of the thalamus in the intensification of the cholinergic activity of the neostriatum.
基于与维持特定姿势相关的工具性防御反射模型，对34只狗进行了慢性实验，所获数据表明，新纹状体胆碱能系统的激活会导致感觉和运动领域出现大量变化。对运动行为的影响主要通过对同侧尾状核胆碱能系统的作用观察到，表现为运动紧张性成分增强、运动相性成分受抑制以及运动活动受限，直至完全停止。对感觉机制的影响通过对新纹状体胆碱能系统的同侧和对侧作用观察到，表现为重要信号分辨能力的提高，显然是通过抑制非特异性传入信息流实现的。文中还介绍了丘脑CM-Pf复合体胆碱反应系统在增强新纹状体胆碱能活性方面的重要作用。
