A theory of the functional organization of the neostriatum and the neostriatal control of voluntary movement.

A theory of the intrinsic, functional organization of the neostriatum and the neostriatal control of voluntary movement is presented. The cell types of neostriatum are described in accordance with the classification scheme of Pasik, Pasik and DiFiglia (ref. 204) and their suspected neurotransmitters are identified. The functional relations between the afferent projections to neostriatum and the intrinsic elements of neostriatum are described. A division of the neostriatal efferents into two functional cell systems is conceived, in which one efferent system, the Spiny I cell matrix, is thought to be represented by a lateral inhibitory network comprised of the common Spiny I neurons which inhibit their targets, while another is termed the Spiny II cell cluster and consists of the far less numerous excitatory efferents of neostriatum (the Spiny II cells) and is represented by clusters of neurons, the members of each cluster consisting of one excitatory efferent neuron and three interneurons. The implications of this view for neostriatal input--output relations are discussed, and the theory is developed by reference to a variety of converging lines of empirical evidence, and is used to interpret the effects of various pharmacologic strategies which have been employed to achieve symptom management in disorders of voluntary movement. In the course of this review, there emerges an integrative theory of the principles governing the neostriatal control of voluntary movement.