Groves P M
Brain Res. 1983 Mar;286(2):109-32. doi: 10.1016/0165-0173(83)90011-5.
A theory of the intrinsic, functional organization of the neostriatum and the neostriatal control of voluntary movement is presented. The cell types of neostriatum are described in accordance with the classification scheme of Pasik, Pasik and DiFiglia (ref. 204) and their suspected neurotransmitters are identified. The functional relations between the afferent projections to neostriatum and the intrinsic elements of neostriatum are described. A division of the neostriatal efferents into two functional cell systems is conceived, in which one efferent system, the Spiny I cell matrix, is thought to be represented by a lateral inhibitory network comprised of the common Spiny I neurons which inhibit their targets, while another is termed the Spiny II cell cluster and consists of the far less numerous excitatory efferents of neostriatum (the Spiny II cells) and is represented by clusters of neurons, the members of each cluster consisting of one excitatory efferent neuron and three interneurons. The implications of this view for neostriatal input--output relations are discussed, and the theory is developed by reference to a variety of converging lines of empirical evidence, and is used to interpret the effects of various pharmacologic strategies which have been employed to achieve symptom management in disorders of voluntary movement. In the course of this review, there emerges an integrative theory of the principles governing the neostriatal control of voluntary movement.
本文提出了一种关于新纹状体的内在功能组织以及新纹状体对自主运动控制的理论。新纹状体的细胞类型根据帕西克、帕西克和迪菲利亚（参考文献204）的分类方案进行描述，并确定了它们可能的神经递质。描述了传入新纹状体的投射与新纹状体内在成分之间的功能关系。设想将新纹状体传出纤维分为两个功能细胞系统，其中一个传出系统，即棘状I细胞基质，被认为由一个由共同的棘状I神经元组成的侧抑制网络代表，这些神经元抑制它们各自的靶点；而另一个被称为棘状II细胞簇，由数量少得多的新纹状体兴奋性传出纤维（棘状II细胞）组成，并由神经元簇代表，每个簇的成员由一个兴奋性传出神经元和三个中间神经元组成。讨论了这种观点对新纹状体输入 - 输出关系的影响，并通过参考各种相互印证的经验证据来发展该理论，并用它来解释为实现自主运动障碍症状管理而采用的各种药理学策略的效果。在这篇综述过程中，出现了一种关于支配新纹状体对自主运动控制的原理的综合理论。
