Gascoyne S C, King A A, Laurenson M K, Borner M, Schildger B, Barrat J
Institute of Zoology, London, United Kingdom.
Onderstepoort J Vet Res. 1993 Dec;60(4):415-20.
Lycaon pictus is amongst the most endangered wildlife species in Africa. In 1990 rabies virus was isolated from the brain of an adult Lycaon found dead in the Serengeti region of Tanzania. One adult and six pups of the same pack feeding on the carcass showed clinical signs and rabies was suspected; within two days they had disappeared and are presumed to have died. Subsequently, two Lycaon packs in the Serengeti National Park were given inactivated rabies vaccine either by dart or by parenteral inoculation following anaesthesia. Lycaon sera which had been collected over the previous two years and sera collected pre- and post-vaccination were examined for the presence of rabies virus neutralizing antibody. Three of 12 unvaccinated Lycaon had antibody levels > 0.5 IU/ml; post-vaccination samples from two Lycaon showed increased antibody levels. Between four and ten months post-vaccination, at least four of the vaccinated animals had died from unknown causes. Issues relating to wildlife vaccination and veterinary intervention in conservation are discussed.
非洲野犬是非洲最濒危的野生动物物种之一。1990年，从坦桑尼亚塞伦盖蒂地区发现死亡的一只成年非洲野犬的大脑中分离出狂犬病病毒。同一群中以该尸体为食的一只成年野犬和六只幼犬出现了临床症状，怀疑感染狂犬病；两天内它们消失了，推测已经死亡。随后，塞伦盖蒂国家公园的两群非洲野犬通过麻醉后注射或皮下接种的方式接种了狂犬病灭活疫苗。检测了过去两年收集的非洲野犬血清以及接种疫苗前后收集的血清中是否存在狂犬病病毒中和抗体。12只未接种疫苗的非洲野犬中有3只抗体水平>0.5 IU/ml；两只接种疫苗的非洲野犬接种后的样本显示抗体水平升高。接种疫苗后四至十个月间，至少有四只接种疫苗的动物死于不明原因。文中讨论了野生动物疫苗接种以及保护中的兽医干预相关问题。
