对氯胍有反应且具有毛细胞白血病特征的巨脾肿大

Massive splenomegaly responsive to proguanil and with features of hairy cell leukaemia.

作者信息

Yermiyahu T, Maislos M, Shneider A, Ben Meir D, Lowenthal M N

机构信息

Haematology Laboratory, Soroka Medical Centre of Kupat Holim, Beer Sheva, Israel.

出版信息

Trans R Soc Trop Med Hyg. 1995 Mar-Apr;89(2):194-6. doi: 10.1016/0035-9203(95)90492-1.

DOI:10.1016/0035-9203(95)90492-1

PMID:7778147

Abstract

A recent Ethiopian immigrant to Israel presented with pneumococcal sepsis, massive splenomegaly and lymph-adenopathy. Investigations revealed many features of both hairy cell leukaemia (HCL) and hyperreactive malarious splenomegaly (HMS). Proguanil therapy for HMS was followed by rapid, marked decrease in spleen size, disappearance of the tartrate-resistant acid phosphatase-positive cells characteristic of HCL, and increasing eosinophilia, but unchanged lymphadenopathy.

摘要

一名近期从埃塞俄比亚移民到以色列的患者，出现了肺炎球菌败血症、巨大脾肿大和淋巴结病。检查发现了毛细胞白血病（HCL）和高反应性疟疾性脾肿大（HMS）的许多特征。针对HMS的氯胍治疗后，脾脏大小迅速显著减小，HCL特有的耐酒石酸酸性磷酸酶阳性细胞消失，嗜酸性粒细胞增多，但淋巴结病无变化。