单纯恶性疟原虫感染中的发热：奎宁和对乙酰氨基酚的作用

Fever in uncomplicated Plasmodium falciparum infection: effects of quinine and paracetamol.

作者信息

Krishna S, Supanaranond W, Pukrittayakamee S, ter Kuile F, Supputamangkol Y, Attatamsoonthorn K, Ruprah M, White N J

机构信息

Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

出版信息

Trans R Soc Trop Med Hyg. 1995 Mar-Apr;89(2):197-9. doi: 10.1016/0035-9203(95)90494-8.

DOI:10.1016/0035-9203(95)90494-8

PMID:7778148

Abstract

The effects of quinine and paracetamol on fever were studied in 21 adult patients with acute uncomplicated falciparum malaria. Quinine alone (n = 7) had no significant effect on fever, whereas paracetamol given 2 h after quinine (n = 7) or 2 h before quinine (n = 7) reduced temperature by a mean of 2.1 degrees C (standard deviation [SD] 0.95) and 2.1 degrees C (SD 0.79) respectively. A temperature reduction of 1 degree C was associated with a mean decrement of 9.7 beats/min (SD 3.3) in the pulse rate. Quinine does not possess useful antipyretic activity.

摘要

对21例急性非复杂性恶性疟的成年患者研究了奎宁和对乙酰氨基酚对发热的影响。单独使用奎宁（n = 7）对发热无显著影响，而在奎宁给药2小时后给予对乙酰氨基酚（n = 7）或在奎宁给药2小时前给予对乙酰氨基酚（n = 7），体温分别平均降低2.1℃（标准差[SD] 0.95）和2.1℃（SD 0.79）。体温每降低1℃，脉搏率平均下降9.7次/分钟（SD 3.3）。奎宁不具有有效的退热活性。