Kochar Dhanpat K, Gupta Vikas, Kochar Abhishek, Acharya Jyoti, Middha Sheetal, Sirohi Parminder, Kochar Sanjay K
Kothari Medical & Research Institute, Bikaner, India.
J Vector Borne Dis. 2010 Sep;47(3):140-4.
This study was conducted to assess the effect of combination treatment of quinine and rabeprazole in the treatment of uncomplicated Plasmodium falciparum malaria.
The study included 50 patients of uncomplicated P. falciparum malaria. Group 1 (25 patients) received quinine and placebo (Q+P) while Group 2 (25 patients) received quinine and rabeprazole (Q+R). Diagnosis was confirmed by peripheral blood film (PBF) and rapid diagnostic test (RDT). Temperature was recorded every 6 h. All patients were followed-up on Days 7, 14, 21, 28 for detailed clinical and parasitological examination.
A total of 20 patients in each group completed the treatment and followed-up for 28 days. While two patients in Group 1 (Q+P) and one patient in Group 2 (Q+R) were lost in follow-up; and seven (Q+P = 4, Q+R =3) patients were withdrawn from the study. Fever clearance time (FCT) of the two groups was also almost similar (Group 1 : 2 = 52.8 : 51.3 h). No statistically significant difference was observed in early treatment failure (ETF) either of the groups. None of the patients in both the groups showed late clinical failure (LCF) or late parasitological failure (LPF). However, there was a significant difference in the parasite clearance rates of the two groups (p<0.05).
The study results suggest that addition of rabeprazole to quinine regimen resulted in an increase in the parasite elimination rate, which may be helpful in reducing the duration of treatment and increasing patient compliance.
本研究旨在评估奎宁与雷贝拉唑联合治疗单纯性恶性疟的效果。
该研究纳入50例单纯性恶性疟患者。第1组（25例患者）接受奎宁和安慰剂（Q+P）治疗，而第2组（25例患者）接受奎宁和雷贝拉唑（Q+R）治疗。通过外周血涂片（PBF）和快速诊断试验（RDT）确诊。每6小时记录一次体温。所有患者在第7、14、21、28天进行随访，以进行详细的临床和寄生虫学检查。
每组共有20例患者完成治疗并进行了28天的随访。第1组（Q+P）有2例患者和第2组（Q+R）有1例患者失访；7例（Q+P = 4，Q+R = 3）患者退出研究。两组的退热时间（FCT）也几乎相似（第1组：2 = 52.8 : 51.3小时）。两组的早期治疗失败（ETF）均未观察到统计学显著差异。两组患者均未出现晚期临床失败（LCF）或晚期寄生虫学失败（LPF）。然而，两组的寄生虫清除率存在显著差异（p<0.05）。
研究结果表明，在奎宁治疗方案中添加雷贝拉唑可提高寄生虫清除率，这可能有助于缩短治疗时间并提高患者依从性。
