Philbin E F, Groff G D, Ries M D, Miller T E
Bassett Healthcare, Cooperstown, New York, USA.
Arthritis Rheum. 1995 Jun;38(6):799-805. doi: 10.1002/art.1780380613.
To evaluate the cardiovascular fitness of a group of patients with severe osteoarthritis (OA).
Thirty-seven patients with end-stage OA were evaluated just before hip or knee replacement surgery. Severity of arthritis was evaluated using standardized techniques. Patients and age- and sex-matched controls underwent a single, maximal, symptom-limited, cardiopulmonary exercise test using arm or leg ergometry and a metabolic cart to measure expired respiratory gases.
Severe musculoskeletal disability and deformity was confirmed in the OA patient group. During exercise testing, OA patients were able to perform physiologically maximal cardiopulmonary exercise. Arthritis patients were noted to be severely deconditioned, with reduced peak oxygen consumption (OA hips mean +/- SD 14.9 +/- 4.2 versus control hips 19.0 +/- 4.6, P < 0.0001; OA knees 12.8 +/- 3.7 versus control knees 17.6 +/- 5.2 ml/kg/minute, P < 0.0005). A trend for more frequent manifestations of coronary heart disease in OA patients than in controls (27% versus 13%; P > 0.05) was also noted.
Patients with end-stage lower extremity OA are severely deconditioned. This may place them at incremental risk for the development of coronary heart disease.
评估一组重度骨关节炎（OA）患者的心血管健康状况。
37例终末期OA患者在进行髋关节或膝关节置换手术前接受评估。采用标准化技术评估关节炎的严重程度。患者以及年龄和性别匹配的对照组进行一次症状限制的最大心肺运动测试，使用手臂或腿部测力计和代谢车测量呼出的呼吸气体。
OA患者组确诊存在严重的肌肉骨骼残疾和畸形。在运动测试期间，OA患者能够进行生理上最大的心肺运动。注意到关节炎患者身体严重失健，峰值耗氧量降低（OA髋关节平均±标准差14.9±4.2，对照组髋关节为19.0±4.6，P<0.0001；OA膝关节为12.8±3.7，对照组膝关节为17.6±5.2毫升/千克/分钟，P<0.0005）。还注意到OA患者冠心病表现比对照组更频繁的趋势（27%对13%；P>0.05）。
终末期下肢OA患者身体严重失健。这可能使他们患冠心病的风险增加。
