Metwally A, Bennett J L, Botros S, Ebeid F
Department of Pharmacology, Theodor Bilharz Research Institute, Giza, Egypt.
Arzneimittelforschung. 1995 Apr;45(4):516-8.
The effects of cimetidine, bicarbonate and glucose on the bioavailability of the two brands of praziquantel (CAS 55268-74-1) available in Egypt were studied in normal healthy volunteers. Brand 1 when coadministered with cimetidine showed elevated concentration of the drug at all time intervals. The difference was statistically significant at 3, 4, 6 and 8 h following treatment. On the other hand coadministration of cimetidine with brand 2 (Distocide) showed elevated concentration of the drug 1 h post treatment. Analysis of the pharmacokinetic parameters revealed insignificant difference comparing brand 1 versus brand 1 plus cimetidine. Significant differences were observed between the elimination rate constant Ke (h-1) for brand 2 (0.017 +/- 0.004) alone versus brand 2 plus cimetidine (0.006 +/- 0.001). Coadministration of bicarbonate or glucose with either brand 2 or brand 1 tended to depress the serum concentration of praziquantel. Possible explanations of these findings are discussed.
在正常健康志愿者中研究了西咪替丁、碳酸氢盐和葡萄糖对埃及现有的两种品牌吡喹酮（CAS 55268-74-1）生物利用度的影响。品牌1与西咪替丁合用时，在所有时间间隔药物浓度均升高。治疗后3、4、6和8小时差异具有统计学意义。另一方面，西咪替丁与品牌2（Distocide）合用时，治疗后1小时药物浓度升高。药代动力学参数分析显示，品牌1与品牌1加西咪替丁相比差异不显著。单独品牌2（0.017±0.004）与品牌2加西咪替丁（0.006±0.001）的消除速率常数Ke（h-1）之间观察到显著差异。碳酸氢盐或葡萄糖与品牌2或品牌1合用时，往往会降低吡喹酮的血清浓度。讨论了这些发现的可能解释。
