在艾姆斯试验中对皂苷诱变活性的分离与研究。
Isolation and studies of the mutagenic activity of saponins in the Ames test.
作者信息
Czeczot H, Rahden-Staroń I, Oleszek W, Jurzysta M
机构信息
Department of Biochemistry, School of Medicine, Warsaw, Poland.
出版信息
Acta Pol Pharm. 1994;51(2):133-6.
PMID:7779177
Abstract
Mutagenic activity of medicagenic acid, medicagenic acid 3-0-glucopyranoside and soyasaponin I was tested by the Ames method with S. typhimurium strains TA97, TA98, TA100, TA102 in the absence and the presence of metabolic activation (S9 mix). These saponins have been isolated and identified from alfalfa roots and clover Trifolium incarnatum seeds. All of them were found to be non-toxic and non-mutagenic for testing doses.
摘要
采用Ames试验，在有无代谢活化（S9混合物）的情况下，用鼠伤寒沙门氏菌菌株TA97、TA98、TA100、TA102测试了苜蓿酸、苜蓿酸3 - O - 吡喃葡萄糖苷和大豆皂苷I的诱变活性。这些皂苷已从苜蓿根和红三叶草种子中分离并鉴定出来。结果发现，在测试剂量下，它们均无毒且无诱变作用。
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