Hata T, Hashimoto M, Senoh D, Hata K, Kitao M, Masumura S
Department of Obstetrics and Gynecology, Shimane Medical University, Izumo, Japan.
Am J Perinatol. 1995 Mar;12(2):135-7. doi: 10.1055/s-2007-994425.
The possible effects of dehydroepiandrosterone sulfate on orbital circulation in 14 term pregnant women were examined by color Doppler flow mapping and pulsed Doppler ultrasound assessments of ophthalmic artery blood flow velocities before and 3 minutes after the intravenous drug injection. Blood pressure, heart rate, peak systolic velocity, end-diastolic velocity, time-averaged mean peak velocity, and pulsatility index were studied. Dehydroepiandrosterone sulfate injected intravenously had little effect on blood pressure, heart rate, and peak systolic velocity, increasing (p < 0.02) the mean end-diastolic velocity from 3.7 +/- 1.7 to 4.9 +/- 2.0 cm/s (mean +/- SD) and the mean time-averaged mean peak velocity (p < 0.02) from 9.8 +/- 3.2 to 12.1 +/- 3.9 cm/s (mean +/- SD). The mean pulsatility index decreased simultaneously (p < 0.02) from 2.75 +/- 0.79 to 2.29 +/- 0.58 (mean +/- SD). Dehydroepiandrosterone sulfate vasodilates the ophthalmic artery, increasing blood flows in term pregnant women, and similar changes might occur in other cerebral vessels. It seems that this vasodilative effect of dehydroepiandrosterone sulfate is expected for treatment of preeclampsia.
通过彩色多普勒血流图以及对14名足月孕妇静脉注射药物前和注射后3分钟的眼动脉血流速度进行脉冲多普勒超声评估，研究硫酸脱氢表雄酮对其眼眶循环的可能影响。对血压、心率、收缩期峰值流速、舒张末期流速、时间平均平均峰值流速和搏动指数进行了研究。静脉注射硫酸脱氢表雄酮对血压、心率和收缩期峰值流速影响不大，可使平均舒张末期流速从3.7±1.7厘米/秒增加至4.9±2.0厘米/秒（平均值±标准差）（p<0.02），并使平均时间平均平均峰值流速从9.8±3.2厘米/秒增加至12.1±3.9厘米/秒（平均值±标准差）（p<0.02）。平均搏动指数同时下降（p<0.02），从2.75±0.79降至2.29±0.58（平均值±标准差）。硫酸脱氢表雄酮可使眼动脉血管扩张，增加足月孕妇的血流量，其他脑血管可能也会发生类似变化。硫酸脱氢表雄酮的这种血管扩张作用似乎有望用于治疗先兆子痫。
