Hata T, Senoh D, Hata K, Kitao M, Masumura S
Department of Obstetrics and Gynecology, Shimane Medical University, Izumo, Japan.
Obstet Gynecol. 1995 Jan;85(1):118-21. doi: 10.1016/0029-7844(94)00295-o.
To investigate the interrelation between estrogen synthesis by the fetoplacental unit and uteroplacental hemodynamics in term pregnancy.
Transvaginal color Doppler flow imaging and pulsed Doppler ultrasonographic assessments were made on ten normal full-term pregnant women before and 3, 5, 10, 30, and 60 minutes after the administration of a 200-mg intravenous dose of dehydroepiandrosterone sulfate (DHAS) in 20 mL of 5% dextrose. Ten normal full-term pregnant women received 20 mL of 5% dextrose as controls. The pulsatility index (PI) values for the uterine artery, heart rate, and mean arterial pressure were recorded. Plasma estradiol (E2) was measured before and 10 minutes after the infusion.
In the DHAS group, uterine artery PI decreased from baseline by 26% (P < .05) after 5 minutes, and the mean reduction was 36% (P < .05) after 10 minutes and 15% (P < .05) after 30 minutes. The PI returned to the baseline value 60 minutes later. In the control group, there was no change in uterine artery PI. No change was found in heart rate or mean arterial blood pressure in the control or DHAS groups. The mean plasma E2 increased from 22.3 +/- 6.6 to 56.2 +/- 24.1 ng/mL (P < .05) 10 minutes after the infusion in DHAS subjects, whereas there was no significant change in plasma E2 in the controls.
Dehydroepiandrosterone sulfate induces a significant decrease in the uterine artery PI, which suggests a possible decrease in uterine vascular impedance in term pregnancy.
探讨足月妊娠时胎儿 - 胎盘单位雌激素合成与子宫 - 胎盘血流动力学之间的相互关系。
对10名正常足月孕妇，静脉注射200mg硫酸脱氢表雄酮（DHAS）溶于20mL 5%葡萄糖溶液中，在给药前及给药后3、5、10、30和60分钟进行经阴道彩色多普勒血流成像和脉冲多普勒超声评估。10名正常足月孕妇接受20mL 5%葡萄糖溶液作为对照。记录子宫动脉搏动指数（PI）值、心率和平均动脉压。在输注前及输注后10分钟测定血浆雌二醇（E2）。
在DHAS组中，子宫动脉PI在5分钟后较基线下降26%（P <.05），10分钟后平均下降36%（P <.05），30分钟后下降15%（P <.05）。60分钟后PI恢复至基线值。在对照组中，子宫动脉PI无变化。对照组和DHAS组的心率或平均动脉血压均无变化。在DHAS组受试者中，输注后10分钟血浆E2平均值从22.3±6.6增加至56.2±24.1ng/mL（P <.05），而对照组血浆E2无显著变化。
硫酸脱氢表雄酮可导致子宫动脉PI显著降低，这提示足月妊娠时子宫血管阻力可能降低。
