Janeway C A
Section of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.
Immunol Today. 1995 May;16(5):223-5. doi: 10.1016/0167-5699(95)80163-4.
T-cell activation occurs when the T-cell receptor (TCR) binds to a self major histocompatibility complex (MHC) molecule carrying a specific peptide. Small changes in peptide structure can alter or inhibit this response. Although this phenomenon is normally attributed to a lowering of the avidity of the ligand for its receptor, recent data suggest that conformational changes in the receptor itself may be playing a critical role, as discussed here by Charles Janeway.
当T细胞受体（TCR）与携带特定肽段的自身主要组织相容性复合体（MHC）分子结合时，T细胞激活就会发生。肽段结构的微小变化可改变或抑制这种反应。尽管这种现象通常归因于配体与其受体亲和力的降低，但最近的数据表明，受体自身的构象变化可能起着关键作用，查尔斯·扬威在此对此进行了讨论。
