人类免疫球蛋白VH基因库。
The human immunoglobulin VH repertoire.
作者信息
Cook G P, Tomlinson I M
机构信息
MRC Centre for Protein Engineering, Cambridge, UK.
出版信息
Immunol Today. 1995 May;16(5):237-42. doi: 10.1016/0167-5699(95)80166-9.
PMID:7779254
Abstract
A complete map of the human immunoglobulin VH locus on chromosome 14 has recently been constructed. The locus is 1100kb in length and contains 51 functional VH segments interspersed amongst a similar number of pseudogenes. Here, Graham Cook and Ian Tomlinson review the organization of the locus, its polymorphism and the repertoire it encodes.
摘要
最近构建了位于14号染色体上的人类免疫球蛋白VH基因座的完整图谱。该基因座长度为1100kb，包含51个功能性VH区段，散布于数量相近的假基因之中。在此，格雷厄姆·库克和伊恩·汤姆林森综述了该基因座的组织、多态性及其所编码的抗体库。
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