Chan T Y, Chan A Y, Ho C S, Critchley J A
Department of Clinical Pharmacology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT.
Hum Exp Toxicol. 1995 Feb;14(2):187-9. doi: 10.1177/096032719501400205.
In this retrospective study, we determined the clinical value of screening for paracetamol in 294 Chinese patients with acute poisoning presenting to the general medical wards at the Prince of Wales Hospital between January 1992 and June 1993. Of the 86 patients suspected of having ingested paracetamol, eight had levels above the recommended 'treatment line'. Of the 208 patients with no suspected paracetamol ingestion, four were found to have elevated but non-toxic plasma levels. The incidence of missed, potentially serious paracetamol poisoning in our patients with no suspected paracetamol ingestion is extremely uncommon. Routine screening of all patients with acute poisoning for toxic plasma paracetamol concentrations is therefore not indicated and should never be a substitute for thorough history taking and physical examination.
在这项回顾性研究中，我们确定了1992年1月至1993年6月期间在威尔士亲王医院普通内科病房就诊的294例急性中毒中国患者中对扑热息痛进行筛查的临床价值。在86例疑似摄入扑热息痛的患者中，有8例的血药浓度高于推荐的“治疗线”。在208例无扑热息痛摄入疑似的患者中，有4例被发现血药浓度升高但无毒。在无扑热息痛摄入疑似的患者中，漏诊潜在严重扑热息痛中毒的发生率极为罕见。因此，不建议对所有急性中毒患者常规筛查血浆扑热息痛的中毒浓度，且这绝不能替代全面的病史采集和体格检查。
