Jeffery H E, Page M
Department of Perinatal and Fetal Medicine, King George V Hospital for Mothers and Babies, Camperdown, NSW, Australia.
Acta Paediatr. 1995 Mar;84(3):245-50. doi: 10.1111/j.1651-2227.1995.tb13623.x.
The frequency and duration of gastro-oesophageal reflux were examined in 40 preterm infants and compared with a previously published healthy cohort of 74 term infants. Selection required that the infants were born between 24 and 32 weeks' gestation, had a normal head ultrasound and were studied at term post-menstrual age. Multi-channel pen recordings of sleep state, movement, breathing and acid reflux were made. In term and preterm infants the frequency and duration of reflux were greatest in active sleep, rare in quiet sleep and significantly less in preterm than term infants in wakefulness and active sleep (p < 0.05). The fewer and shorter episodes in preterm infants could not be explained by sleep state movement, gestational or postnatal age, days intubated, days on oxygen or the lowest pH of reflux episodes.
对40名早产儿的胃食管反流频率和持续时间进行了检查，并与之前发表的74名足月儿健康队列进行了比较。入选要求婴儿出生时孕周在24至32周之间，头部超声正常，并在月经后足月时进行研究。进行了睡眠状态、运动、呼吸和酸反流的多通道笔式记录。在足月儿和早产儿中，反流频率和持续时间在主动睡眠时最高，在安静睡眠时罕见，且在清醒和主动睡眠时，早产儿的反流频率和持续时间明显低于足月儿（p<0.05）。早产儿反流发作次数较少且持续时间较短，这无法用睡眠状态运动、孕周或出生后年龄、插管天数、吸氧天数或反流发作的最低pH值来解释。
