Jeffery H E, Heacock H J
Department of Perinatal and Fetal Medicine, King George V Hospital for Mothers and Babies, Camperdown NSW, Australia.
Arch Dis Child. 1991 Oct;66(10 Spec No):1136-9. doi: 10.1136/adc.66.10_spec_no.1136.
Seventy four normal, healthy newborn babies were studied to examine the relationship between gastro-oesophageal reflux, sleep state, and movement. Multichannel pen recordings were made to determine sleep state, movement, breathing, and reflux. The mean number of reflux episodes per hour was highest in wakefulness, followed by active and indeterminate sleep. In quiet sleep reflux rarely occurred. The mean duration of reflux episodes per hour was longest in active sleep followed by wakefulness, indeterminate and quiet sleep. There was a strong positive correlation between duration of reflux and movement time for wakefulness, active and indeterminate sleep. Movement preceded 88% of all reflux episodes. Physiological reflux occurs in most newborn infants but is clinically inapparent. The results suggest that state and movement are related to the incidence and duration of reflux. Sleep state is therefore an important variable in determining normal values for reflux in infancy since developmentally the amount of sleep time lessens but quiet sleep proportionally increases.
对74名正常、健康的新生儿进行了研究，以检查胃食管反流、睡眠状态和运动之间的关系。通过多通道笔式记录来确定睡眠状态、运动、呼吸和反流情况。每小时反流发作的平均次数在清醒时最高，其次是主动睡眠和不确定睡眠。在安静睡眠时反流很少发生。每小时反流发作的平均持续时间在主动睡眠中最长，其次是清醒、不确定睡眠和安静睡眠。清醒、主动睡眠和不确定睡眠时，反流持续时间与运动时间之间存在很强的正相关。88%的反流发作之前有运动。大多数新生儿会出现生理性反流，但临床上不明显。结果表明，状态和运动与反流的发生率和持续时间有关。因此，睡眠状态是确定婴儿期反流正常值的一个重要变量，因为随着发育，睡眠时间减少，但安静睡眠成比例增加。
