可能有婴儿猝死综合征风险的婴儿的睡眠阶段与胃食管反流
Sleep phase and gastro-oesophageal reflux in infants at possible risk of SIDS.
作者信息
Paton J Y, MacFadyen U M, Simpson H
机构信息
Department of Child Health, University of Leicester.
出版信息
Arch Dis Child. 1989 Feb;64(2):264-9. doi: 10.1136/adc.64.2.264.
The association between gastro-oesophageal reflux and sleep state in 24 infants with confirmed or suspected gastro-oesophageal reflux was studied by monitoring both the pH in the lower oesophagus and polygraphic tracings made during sleep at night. Gastro-oesophageal reflux during the night was confirmed in 20 infants. Three hundred and sixteen precipitous drops of more than one unit of pH were recorded during the studies, 186 during periods of wakefulness. Of 130 drops in pH during sleep, 62 (48%) began during active sleep and 62 during indeterminate sleep. Of the latter, 56 (90%) were associated with brief gross body movements. Only five of the drops in pH (4%) began during quiet sleep. Gastro-oesophageal reflux stopped during active sleep on 56 occasions (43%), in indeterminate sleep in 62 (47%), and in quiet sleep in 12 (9%). Episodes of gastro-oesophageal reflux starting or ending in quiet sleep were uncommon. The occurrence of gastro-oesophageal reflux during active sleep may partly explain why reflux during sleep is a risk factor for pulmonary disease.
通过监测24名确诊或疑似胃食管反流婴儿的食管下段pH值及夜间睡眠时的多导记录，研究了胃食管反流与睡眠状态之间的关系。20名婴儿被证实存在夜间胃食管反流。研究期间记录到316次pH值急剧下降超过1个单位的情况，其中186次发生在清醒期。在睡眠期间记录到的130次pH值下降中，62次（48%）始于主动睡眠期，62次始于不确定睡眠期。在后者中，56次（90%）与明显的全身快速运动有关。只有5次pH值下降（4%）始于安静睡眠期。胃食管反流在主动睡眠期停止56次（43%），在不确定睡眠期停止62次（47%），在安静睡眠期停止12次（9%）。始于或结束于安静睡眠期的胃食管反流发作并不常见。主动睡眠期胃食管反流的发生可能部分解释了为何睡眠期间的反流是肺部疾病的一个危险因素。
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