Nygaard I, Zmolek G
Department of Obstetrics and Gynecology, University of Iowa School of Medicine, Iowa City, USA.
Neurourol Urodyn. 1995;14(2):125-9. doi: 10.1002/nau.1930140205.
This study was undertaken to determine normal values for a modified pad test to be used for testing outcomes of studies addressing therapy for exercise incontinence. Fourteen asymptomatic volunteers who were continent by history completed three similar exercise sessions wearing pre-weighed pads after ingesting phenazopyridine hydrochloride (Pyridium, Parke-Davis, Sandy, UT). The mean pad weight gain for all exercise sessions combined was 3.19 +/- 3.16 g (range 0.1-12.4). The mean area of pyridium staining was 2.66 +/- 3.14 mm. Mean volume voided after the exercise sessions was 193 +/- 108 cc (range 10-625). The Kendall coefficient of concordance used to test the interest reliability was 0.96 for pad weight gain, 0.76 for area of stain, and 0.60 for volume voided. All but one of the subjects had at least one spot of pyridium stain on at least one of the three pads. The increase in pad weight attributable to sweat and vaginal moisture is reproducible in a given individual performing the same exercise routine, but due to the large variation between subjects, we were unable to establish a cut-off value separating continence from incontinence. Adding pyridium did not improve the specificity of the test, despite instructing subjects to milk the urethra and blot before applying the pad.
本研究旨在确定一种改良护垫试验的正常值，该试验用于评估针对压力性尿失禁治疗的研究结果。14名既往无尿失禁症状的志愿者在摄入盐酸非那吡啶（Pyridium，Parke-Davis，桑迪，犹他州）后，穿着预先称重的护垫完成了三次类似的运动。所有运动时段护垫重量增加的平均值为3.19±3.16克（范围0.1 - 12.4）。非那吡啶染色的平均面积为2.66±3.14平方毫米。运动后平均排尿量为193±108毫升（范围10 - 625）。用于测试内部一致性的肯德尔和谐系数，护垫重量增加为0.96，染色面积为0.76，排尿量为0.60。除一名受试者外，其他所有受试者在三块护垫中的至少一块上至少有一处非那吡啶染色。在进行相同运动程序的特定个体中，因汗液和阴道分泌物导致的护垫重量增加是可重复的，但由于个体间差异较大，我们无法确定区分尿失禁和非尿失禁的临界值。尽管指导受试者在放置护垫前挤压尿道并擦拭，但添加非那吡啶并未提高试验的特异性。
