Wall L L, Wang K, Robson I, Stanton S L
Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC 27710.
J Reprod Med. 1990 Jul;35(7):682-4.
Eighteen women with urodynamically proven genuine stress incontinence awaiting surgery and 23 normal, asymptomatic, continent female volunteers took part in a study to compare the accuracy of a qualitative pad test with a quantitative pad-weighing test in detecting urine loss. Each woman took 600 mg of phenazopyridine hydrochloride (Pyridium, Parke-Davis) in three equally divided doses over 18-24 hours and then underwent a standardized, one-hour pad test as described by the International Continence Society. The Pyridium pad test was regarded as positive if there was any orange staining on the pad. The quantitative pad-weighing test was considered positive if there was a weight gain of 1.0 g or more at the end of the one-hour test period. All 18 patients with genuine stress incontinence had positive Pyridium pad tests, and all had pad weight gains of greater than or equal to 1.0 g (mean, 16.5). The maximum pad weight gain in the asymptomatic, continent volunteers was 0.7 g (mean, 0.1), and none was aware of any urinary leakage during the test; however, 12 (52%) had positive Pyridium pad tests. The Pyridium pad test appears 100% sensitive in detecting urine loss in symptomatic women with genuine stress incontinence, but it has a high false-positive rate in healthy, asymptomatic, continent women. If pad-weighing tests are done, the addition of Pyridium generally will not be useful, and if Pyridium is used by itself, the results may be misleading.
18名经尿动力学证实为真性压力性尿失禁且等待手术的女性以及23名正常、无症状、控尿的女性志愿者参与了一项研究，以比较定性护垫试验与定量护垫称重试验在检测尿液丢失方面的准确性。每位女性在18 - 24小时内分三次等量服用600毫克盐酸非那吡啶（Pyridium，帕克·戴维斯公司生产），然后按照国际尿控协会描述的方法进行标准化的1小时护垫试验。如果护垫上有任何橙色染色，则认为非那吡啶护垫试验为阳性。如果在1小时试验期结束时护垫重量增加1.0克或更多，则定量护垫称重试验被认为是阳性。所有18名真性压力性尿失禁患者的非那吡啶护垫试验均为阳性，且所有患者的护垫重量增加均大于或等于1.0克（平均为16.5克）。无症状、控尿志愿者的护垫最大重量增加为0.7克（平均为0.1克），且在试验期间没有人意识到有任何尿液泄漏；然而，12名（52%）志愿者的非那吡啶护垫试验为阳性。非那吡啶护垫试验在检测有症状的真性压力性尿失禁女性的尿液丢失方面似乎具有100%的敏感性，但在健康、无症状、控尿的女性中具有较高的假阳性率。如果进行护垫称重试验，添加非那吡啶通常没有用，如果单独使用非那吡啶，结果可能会产生误导。
