Shen J, Xu Y C, Hu X
Department of Epidemiology, Nanjing Medical University.
Zhonghua Liu Xing Bing Xue Za Zhi. 1995 Apr;16(2):105-8.
A genetic epidemiologic case-control study including 407 pedigrees (249 cases and 158 controls) was carried out to estimate the segregation ratio and the hereditability (h2) of esophageal cancer by using the method of Li-Mantel-Gart and Falconer, respectively, and to compare the genetic epidemiologic features from the other cancers. The results showed that the segregation ratio of esophageal cancer was 0.1347, significantly less than 0.25 and the genetic model belonged to polygenetics. The h2 of esophageal cancer was 21.41%, 20.23% for female and 13.57% for male. It is concluded that genetic factor is one of the risk factors for esophageal cancer and specially of importance for female, but it is not a main risk factor for esophageal cancer. The results of comparative epidemiologic study among the cancers of lung, stomach, liver and large bowel showed that the segregation ratios of the cancers (except stomach, no data) were all less than 0.25, and the h2 of gastric and liver cancers were higher, which were 52.40% and 51.85%, respectively.
开展了一项遗传流行病学病例对照研究，纳入407个家系（249例病例和158例对照），分别采用Li-Mantel-Gart法和Falconer法估计食管癌的分离比和遗传度（h2），并比较其与其他癌症的遗传流行病学特征。结果显示，食管癌的分离比为0.1347，显著低于0.25，遗传模式属于多基因遗传。食管癌的h2为21.41%，女性为20.23%，男性为13.57%。结论是，遗传因素是食管癌的危险因素之一，对女性尤为重要，但并非食管癌的主要危险因素。肺癌、胃癌、肝癌和大肠癌的比较流行病学研究结果显示，这些癌症（胃癌无数据除外）的分离比均小于0.25，胃癌和肝癌的h2较高，分别为52.40%和51.85%。
