Jin Y T, He X Z
Anhui Medical University, Hefei.
Zhonghua Yi Xue Za Zhi. 1993 Dec;73(12):753-5, 774.
To determine the relation between genetic factor and lung cancer We selected 370 lung cancer probands in Xuanwei county, Yunan Province China. The data on 370 nuclear families were analysed. The segregation ratio of lung cancer was 0.15 and the genetic model of lung cancer belonged to polygenetics. The heritability of lung cancer was 24.6%, 14.6% for male and 37.8% for female. It is concluded that genetic factor is one of the risk factors for lung cancer is specially of importance for females, but it is not a main risk factor for lung cancer. Our results are helpful in complaining the high incidence of lung cancer in females in Xuanwei county.
为确定遗传因素与肺癌之间的关系，我们在中国云南省宣威县选取了370名肺癌先证者。对370个核心家庭的数据进行了分析。肺癌的分离比为0.15，肺癌的遗传模式属于多基因遗传。肺癌的遗传度为24.6%，男性为14.6%，女性为37.8%。结论是，遗传因素是肺癌的危险因素之一，对女性尤为重要，但它不是肺癌的主要危险因素。我们的结果有助于解释宣威县女性肺癌的高发病率。
