Ohno Y, Hosokawa K, Tamura T, Fujimoto Y, Kawashima M, Koishi K, Okada H
Department of Obstetrics and Gynecology, Kyoto Prefectural University of Medicine, Japan.
Hum Reprod. 1995 Mar;10(3):708-11. doi: 10.1093/oxfordjournals.humrep.a136020.
The present study was undertaken to evaluate a possible relationship between the endometrial concentrations of oestrogen receptor (ER) or progesterone receptor (PR), and the sonographic appearance of human endometrium. Sonographic assessments and aspirations of the endometrium at the time of or prior to ovulation were made in 48 cycles of 45 infertile women. Endometrial patterns were classified as A, triple line pattern, or B, not triple line, on the basis of echogenicity. We did not find a correlation between ER or PR and serum oestradiol or endometrial thickness. Furthermore, serum oestradiol concentrations were not correlated with endometrial pattern or thickness. The only significant correlations were found between the concentrations of ER and PR in the pattern A endometrium (r = 0.80, P < 0.01) and in the pattern B endometrium (r = 0.49, P < 0.05). There were no differences in the mean concentrations of ER and PR despite differences in endometrial pattern and thickness. However, PR was measured at > 800 fmol/mg protein in 12 out of 38 pattern A endometria, while PR was < 800 fmol/mg protein in all pattern B endometria. These data suggest that high PR expression in the pre-ovulatory period is related to an adequate endometrial growth and thereby increases the responsiveness of the endometrium to progesterone stimulation after ovulation.
本研究旨在评估雌激素受体（ER）或孕激素受体（PR）的子宫内膜浓度与人类子宫内膜超声表现之间的可能关系。对45名不孕女性的48个周期进行了超声评估，并在排卵时或排卵前对子宫内膜进行了抽吸。根据回声性，子宫内膜模式分为A，三线模式，或B，非三线模式。我们未发现ER或PR与血清雌二醇或子宫内膜厚度之间存在相关性。此外，血清雌二醇浓度与子宫内膜模式或厚度无关。仅在A模式子宫内膜（r = 0.80，P < 0.01）和B模式子宫内膜（r = 0.49，P < 0.05）中发现ER和PR浓度之间存在显著相关性。尽管子宫内膜模式和厚度存在差异，但ER和PR的平均浓度没有差异。然而，在38个A模式子宫内膜中的12个中，PR测量值> 800 fmol/mg蛋白，而在所有B模式子宫内膜中PR < 800 fmol/mg蛋白。这些数据表明，排卵前期高PR表达与子宫内膜的充分生长有关，从而增加了排卵后子宫内膜对孕激素刺激的反应性。
