Aiba T, Tanaka R, Koike T, Kameyama S, Takeda N, Komata T
Department of Neurosurgery, Niigata University, Japan.
J Neurosurg. 1995 Jul;83(1):56-9. doi: 10.3171/jns.1995.83.1.0056.
The authors have reviewed the clinical records of 110 patients with intracranial cavernous malformations diagnosed by histological examination and/or magnetic resonance imaging over a mean follow-up period of 4.71 years. These cases were divided, based on their presentation, into a hemorrhage group, a seizure group, and an incidentally diagnosed group. The rate of subsequent symptomatic bleeding was investigated in relation to age at onset, sex, and location of the initial lesion. A high rate of subsequent symptomatic bleeding episodes was found in the hemorrhage group, especially among younger females. The nonhemorrhagic-onset cases had a very low incidence of bleeding. The outcome was generally good, except in patients with lesions in the basal ganglia and brainstem. These findings will be helpful in planning a rational therapeutic strategy for intracranial cavernous malformations.
作者回顾了110例经组织学检查和/或磁共振成像诊断为颅内海绵状畸形患者的临床记录，平均随访期为4.71年。这些病例根据其临床表现分为出血组、癫痫组和偶然诊断组。研究了后续症状性出血率与发病年龄、性别及初始病变部位的关系。发现出血组后续症状性出血发作率较高，尤其是年轻女性。非出血性起病的病例出血发生率很低。除基底节和脑干有病变的患者外，总体预后良好。这些发现将有助于制定合理的颅内海绵状畸形治疗策略。
