白色念珠菌肉豆蔻酰辅酶A：蛋白质N-肉豆蔻酰转移酶强效和选择性二肽抑制剂的设计与合成 - Suppr

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超能文献

Design and syntheses of potent and selective dipeptide inhibitors of Candida albicans myristoyl-CoA:protein N-myristoyltransferase.

作者信息

Devadas B, Zupec M E, Freeman S K, Brown D L, Nagarajan S, Sikorski J A, McWherter C A, Getman D P, Gordon J I

机构信息

Department of Medicinal and Structural Chemistry, G. D. Searle and Company, St. Louis, Missouri 63198, USA.

出版信息

J Med Chem. 1995 May 26;38(11):1837-40. doi: 10.1021/jm00011a001.

DOI:10.1021/jm00011a001

PMID:7783114

Abstract

摘要

相似文献

Design and syntheses of potent and selective dipeptide inhibitors of Candida albicans myristoyl-CoA:protein N-myristoyltransferase.白色念珠菌肉豆蔻酰辅酶A：蛋白质N-肉豆蔻酰转移酶强效和选择性二肽抑制剂的设计与合成

J Med Chem. 1995 May 26;38(11):1837-40. doi: 10.1021/jm00011a001.

Design and synthesis of novel imidazole-substituted dipeptide amides as potent and selective inhibitors of Candida albicans myristoylCoA:protein N-myristoyltransferase and identification of related tripeptide inhibitors with mechanism-based antifungal activity.新型咪唑取代二肽酰胺的设计与合成：作为白色念珠菌肉豆蔻酰辅酶A：蛋白质N-肉豆蔻酰转移酶的强效和选择性抑制剂以及具有基于机制的抗真菌活性的相关三肽抑制剂的鉴定

J Med Chem. 1997 Aug 1;40(16):2609-25. doi: 10.1021/jm970094w.

Scanning alanine mutagenesis and de-peptidization of a Candida albicans myristoyl-CoA:protein N-myristoyltransferase octapeptide substrate reveals three elements critical for molecular recognition.白色念珠菌肉豆蔻酰辅酶A：蛋白质N-肉豆蔻酰转移酶八肽底物的扫描丙氨酸诱变和去肽化揭示了分子识别的三个关键元件。

J Biol Chem. 1997 May 2;272(18):11874-80. doi: 10.1074/jbc.272.18.11874.

Crystal structures of Candida albicans N-myristoyltransferase with two distinct inhibitors.白色念珠菌N-肉豆蔻酰转移酶与两种不同抑制剂的晶体结构

Chem Biol. 2002 Oct;9(10):1119-28. doi: 10.1016/s1074-5521(02)00240-5.

Synthesis of myristoyl CoA analogues and myristoyl peptides as inhibitors of myristoyl CoA:protein N-myristoyltransferase.肉豆蔻酰辅酶A类似物和肉豆蔻酰肽作为肉豆蔻酰辅酶A：蛋白质N-肉豆蔻酰转移酶抑制剂的合成

J Pharm Sci. 1994 Feb;83(2):233-8. doi: 10.1002/jps.2600830224.

N-myristoylation of Arf proteins in Candida albicans: an in vivo assay for evaluating antifungal inhibitors of myristoyl-CoA: protein N-myristoyltransferase.白色念珠菌中Arf蛋白的N-肉豆蔻酰化：一种用于评估肉豆蔻酰辅酶A：蛋白质N-肉豆蔻酰转移酶抗真菌抑制剂的体内试验。

Microbiology (Reading). 1997 Feb;143 ( Pt 2):357-366. doi: 10.1099/00221287-143-2-357.

The Candida albicans myristoyl-CoA:protein N-myristoyltransferase gene. Isolation and expression in Saccharomyces cerevisiae and Escherichia coli.白色念珠菌肉豆蔻酰辅酶A：蛋白质N-肉豆蔻酰转移酶基因。在酿酒酵母和大肠杆菌中的分离与表达。

J Biol Chem. 1992 Apr 25;267(12):8591-8.

Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 3.新型苯并呋喃类化合物的设计与合成——作为一类靶向真菌N-肉豆蔻酰转移酶的新型抗真菌剂。第3部分。

Bioorg Med Chem Lett. 2003 Jan 6;13(1):87-91. doi: 10.1016/s0960-894x(02)00844-2.

Structure of N-myristoyltransferase with bound myristoylCoA and peptide substrate analogs.结合肉豆蔻酰辅酶A和肽底物类似物的N-肉豆蔻酰转移酶的结构。

Nat Struct Biol. 1998 Dec;5(12):1091-7. doi: 10.1038/4202.

Selective peptidic and peptidomimetic inhibitors of Candida albicans myristoylCoA: protein N-myristoyltransferase: a new approach to antifungal therapy.白色念珠菌肉豆蔻酰辅酶A：蛋白质N-肉豆蔻酰转移酶的选择性肽类和拟肽类抑制剂：抗真菌治疗的新方法

Biopolymers. 1997;43(1):43-71. doi: 10.1002/(SICI)1097-0282(1997)43:1<43::AID-BIP5>3.0.CO;2-0.

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