Propst-Ricciuti B
J Gen Virol. 1976 Jun;31(3):323-30. doi: 10.1099/0022-1317-31-3-323.
Infection of glucose, sulphur or nitrogen starved cells with MS2 virus results in the production of progeny virus but the absence of cell lysis and the failure of progeny virus release. Addition of glucose of sulphur to the correspondingly starved cells results in the normal release of virus within 40 to 60 min. Return of nitrogen to nitrogen-starved cells, however, does not result in the release of virus, even after 1 1/2 h. In experiments with uninfected, starved cells it was found that glucose or sulphur starved cells begin dividing within 45 min after the limiting compound is returned. In contrast, nitrogen-starved cultures have not begun to divide 1 1/2 after the return of nitrogen. The correlation between the time it takes for starved, infected cultures to resume lysis after the return of the limiting compound and the time similarly starved, but infected, cells normally begin division after addition of the limiting compound supports the hypothesis that lysis by RNA phage is related to cell division and may result at the time of cell division from failure of the cells to divide properly.
用MS2病毒感染葡萄糖、硫或氮饥饿的细胞会产生子代病毒，但不会导致细胞裂解，子代病毒也无法释放。向相应饥饿的细胞中添加葡萄糖或硫会导致病毒在40至60分钟内正常释放。然而，向氮饥饿的细胞中重新添加氮，即使在1个半小时后，也不会导致病毒释放。在用未感染的饥饿细胞进行的实验中发现，葡萄糖或硫饥饿的细胞在限制化合物重新添加后45分钟内开始分裂。相比之下，氮饥饿的培养物在重新添加氮1个半小时后仍未开始分裂。饥饿的感染培养物在限制化合物重新添加后恢复裂解所需的时间，与同样饥饿但未感染的细胞在添加限制化合物后正常开始分裂的时间之间的相关性，支持了以下假设：RNA噬菌体引起的裂解与细胞分裂有关，可能是由于细胞在分裂时未能正常分裂所致。
