Li P, Fujio S
Graduate School, China Academy of Traditional Chinese Medicine, Beijing.
J Tradit Chin Med. 1995 Mar;15(1):48-52.
Effects of Chai Ling Tang (a decoction of medicinal herbs) on passive Heymann nephritis (PHN) in rats, a model similar to human membranous nephropathy, were examined. Four hundred mg/kg (body weight) of Chai Ling Tang, or 240 mg/kg B.W. of Xiao Chai Hu Tang, or 130 mg/kg B.W. of Chai Hu (Radix Bupleuri), Ban Xia (Rhizoma Pinelliae) and Sheng Jiang (Rhizoma Zingiberis Recens) were intraperitoneally injected respectively into three groups of female Wistar rats once a day starting from 5 days before intravenous injection of anti-FxlA antibody to the end of the experiment. Another group of rats intraperitoneally injected with phosphate buffered saline (PBS) was used as the control. It was found that the excretion of urinary protein was significantly suppressed in the Chai Ling Tang treated group (52.2 +/- 46.9 mg/day) as compared to that in the PBS control group (276.5 +/- 127.0 mg/day) 15 days after anti-FxlA antibody injection (P < 0.01). The decrease of serum albumin and total protein, and the increase of serum total cholesterol were significantly inhibited in the Chai Ling Tang treated group as compared to that in the control group (P < 0.05, P < 0.05 and P < 0.01 respectively). It is therefore concluded that proteinuria in PHN can be significantly suppressed by Chai Ling Tang.
研究了柴苓汤（一种草药煎剂）对大鼠被动型海曼肾炎（PHN）的影响，该模型类似于人类膜性肾病。分别将400mg/kg（体重）的柴苓汤、240mg/kg体重的小柴胡汤或130mg/kg体重的柴胡（柴胡根）、半夏（半夏根茎）和生姜（鲜姜根茎）腹腔注射到三组雌性Wistar大鼠中，从静脉注射抗FxlA抗体前5天开始，每天一次，直至实验结束。另一组腹腔注射磷酸盐缓冲盐水（PBS）的大鼠作为对照。结果发现，抗FxlA抗体注射15天后，柴苓汤治疗组（52.2±46.9mg/天）的尿蛋白排泄量与PBS对照组（276.5±127.0mg/天）相比显著降低（P<0.01）。与对照组相比，柴苓汤治疗组血清白蛋白和总蛋白的降低以及血清总胆固醇的升高均受到显著抑制（分别为P<0.05、P<0.05和P<0.01）。因此得出结论，柴苓汤可显著抑制PHN中的蛋白尿。
