Speer M E, Taber L H, Yow M D, Rudolph A J, Urteaga J, Waller S
J Pediatr. 1976 Jul;89(1):91-5. doi: 10.1016/s0022-3476(76)80939-0.
During 1973 a nonendemic mucoid strain of Escherichia coli entered the nursery of a hospital in Houston. This organism caused septicemia and was associated with a high incidence of necrotizing enterocolitis. The illness was fulminant and characterized by apnea, abdominal distension, and shock. Diarrhea was not a feature of the symptom complex. The epidemic organism was nontypable. Assays for invasiveness, enterotoxin production, and Kl antigen were negative. Surveillance revealed a colonization rate of 14%, an attack rate in colonized infants of 19.5%, and a mortality rate of 87.5%. These data suggest that in certain instances the specific bowel flora may increase the incidence and severity of NEC.
1973年期间，一种非地方性的黏液样大肠杆菌菌株进入了休斯顿一家医院的托儿所。这种微生物引起败血症，并与坏死性小肠结肠炎的高发病率相关。病情凶险，以呼吸暂停、腹胀和休克为特征。腹泻不是症状复合体的特征。该流行菌株无法分型。侵袭性、肠毒素产生及K1抗原检测均为阴性。监测显示定植率为14%，定植婴儿的发病率为19.5%，死亡率为87.5%。这些数据表明，在某些情况下，特定的肠道菌群可能会增加坏死性小肠结肠炎的发病率和严重程度。
