坏死性小肠结肠炎的流行病学
Epidemiology of necrotizing enterocolitis.
作者信息
Kosloske A M
机构信息
Department of Surgery, Ohio State University College of Medicine, Columbus.
出版信息
Acta Paediatr Suppl. 1994;396(Suppl 396):2-7. doi: 10.1111/j.1651-2227.1994.tb13232.x.
Abstract
Necrotizing enterocolitis (NEC) is a worldwide problem that has emerged in the past 25 years as the most common gastrointestinal emergency in neonatal intensive care units (NICU). In the United States the incidence ranges from 1 to 7.7% of NICU admissions. Ninety percent of the patients are premature infants. Mucosal injury, bacterial colonization and formula feeding are the three major pathogenetic factors that have been documented in most infants who have developed NEC. However, NEC may develop only if a threshold of injury, imposed by the coincidence of at least two of three events (intestinal ischemia, pathogenic bacteria, and excess of protein substrate) is exceeded. Immunological immaturity of the gut in premature babies may represent the crucial risk factor.
摘要
坏死性小肠结肠炎（NEC）是一个全球性问题，在过去25年中已成为新生儿重症监护病房（NICU）中最常见的胃肠道急症。在美国，NICU入院患者中NEC的发病率为1%至7.7%。90%的患者为早产儿。黏膜损伤、细菌定植和配方奶喂养是大多数发生NEC的婴儿中已被记录的三个主要致病因素。然而，只有当由三个事件（肠道缺血、病原菌和蛋白质底物过量）中至少两个事件同时发生所导致的损伤阈值被超过时，才可能发生NEC。早产儿肠道的免疫不成熟可能是关键的危险因素。
相似文献
1
Epidemiology of necrotizing enterocolitis.坏死性小肠结肠炎的流行病学
Acta Paediatr Suppl. 1994;396(Suppl 396):2-7. doi: 10.1111/j.1651-2227.1994.tb13232.x.
2
3
A review of evidence for a role of magnesium and possibly copper deficiency in necrotizing enterocolitis.
Magnes Res. 1996 Mar;9(1):55-66.
4
Neonatal necrotizing enterocolitis, a disease of the immature intestinal mucosal barrier.
Acta Paediatr Suppl. 1994;396:27-32. doi: 10.1111/j.1651-2227.1994.tb13238.x.
5
6
7
Necrotizing enterocolitis in premature infants transferred back to community hospitals.
Am J Dis Child. 1983 Jun;137(6):563-5. doi: 10.1001/archpedi.1983.02140320039008.
8
Necrotizing enterocolitis: a review of pathogenetic mechanisms and implications for prevention.坏死性小肠结肠炎：发病机制综述及其预防意义
Pediatr Pathol. 1993 May-Jun;13(3):357-69. doi: 10.3109/15513819309048223.
9
Necrotizing enterocolitis in a perinatal centre.围产期中心的坏死性小肠结肠炎
J Paediatr Child Health. 1992 Feb;28(1):47-9. doi: 10.1111/j.1440-1754.1992.tb02616.x.
10
[Pathogenetic concepts of neonatal necrotizing enterocolitis].
Klin Padiatr. 1993 Sep-Oct;205(5):317-24. doi: 10.1055/s-2007-1025242.
引用本文的文献
1
The prediction models for the optimal timing of surgical intervention for necrotizing enterocolitis: nomogram vs. five machine learning models.坏死性小肠结肠炎手术干预最佳时机的预测模型：列线图与五种机器学习模型
Pediatr Surg Int. 2025 Aug 20;41(1):260. doi: 10.1007/s00383-025-06163-y.
2
Surgical prediction of neonatal necrotizing enterocolitis based on radiomics and clinical information.基于放射组学和临床信息的新生儿坏死性小肠结肠炎的外科预测。
Abdom Radiol (NY). 2024 Apr;49(4):1020-1030. doi: 10.1007/s00261-023-04157-9. Epub 2024 Jan 29.
3
Determinants of microbial colonization in the premature gut.早产儿肠道微生物定植的决定因素。
Mol Med. 2023 Jul 5;29(1):90. doi: 10.1186/s10020-023-00689-4.
4
Necrotizing enterocolitis: recent advances in treatment with translational potential.坏死性小肠结肠炎：具有转化潜力的治疗新进展。
Pediatr Surg Int. 2023 May 29;39(1):205. doi: 10.1007/s00383-023-05476-0.
5
Imaging for Diagnosis and Assessment of Necrotizing Enterocolitis.坏死性小肠结肠炎的诊断与评估影像学检查
Newborn (Clarksville). 2022 Jan-Mar;1(1):182-189. doi: 10.5005/jp-journals-11002-0002. Epub 2022 Mar 31.
6
Intra-Amniotic Administration-An Emerging Method to Investigate Necrotizing Enterocolitis, In Vivo ().羊膜腔内给药——一种用于研究坏死性小肠结肠炎的新兴方法：体内（）。
Nutrients. 2022 Nov 12;14(22):4795. doi: 10.3390/nu14224795.
7
The Prevalence of Necrotizing Enterocolitis and Associated Factors Among Enteral Fed Preterm and Low Birth Weight Neonates Admitted in Selected Public Hospitals in Addis Ababa, Ethiopia: A Cross-sectional Study.埃塞俄比亚亚的斯亚贝巴部分公立医院收治的经肠内喂养的早产和低出生体重新生儿坏死性小肠结肠炎的患病率及相关因素：一项横断面研究。
Glob Pediatr Health. 2021 May 27;8:2333794X211019695. doi: 10.1177/2333794X211019695. eCollection 2021.
8
Necrotizing enterocolitis intestinal barrier function protection by antenatal dexamethasone and surfactant-D in a rat model.产前地塞米松和表面活性剂-D 对坏死性小肠结肠炎肠屏障功能的保护作用：大鼠模型研究。
Pediatr Res. 2021 Oct;90(4):768-775. doi: 10.1038/s41390-020-01334-0. Epub 2021 Jan 19.
9
Introducing multi-modal enteral medication reduced morbidity and mortality associated with necrotising enterocolitis.引入多模式肠内给药可降低与坏死性小肠结肠炎相关的发病率和死亡率。
Acta Paediatr. 2021 Feb;110(2):458-464. doi: 10.1111/apa.15466. Epub 2020 Jul 22.
10
Developmental 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure of either parent enhances the risk of necrotizing enterocolitis in neonatal mice.父母双方的二噁英暴露都增加了新生小鼠患坏死性小肠结肠炎的风险。
Birth Defects Res. 2020 Oct;112(16):1209-1223. doi: 10.1002/bdr2.1742. Epub 2020 Jun 9.
本文引用的文献
1
NECROTIZING ENTEROCOLITIS IN THE PREMATURE INFANT.早产儿坏死性小肠结肠炎
Radiology. 1964 Nov;83:879-87. doi: 10.1148/83.5.879.
2
THE MASTER SWITCH OF LIFE.生命的主开关。
Sci Am. 1963 Dec;209:92-106. doi: 10.1038/scientificamerican1263-92.
3
[Ulcero-necrotic enterocolitis in premature infants].
Sem Hop. 1959 Apr 24;35(19/4):1428-36/P.
4
Randomized trial of umbilical arterial catheter position: clinical outcome.脐动脉导管位置的随机试验：临床结果
Acta Paediatr. 1993 Feb;82(2):173-6. doi: 10.1111/j.1651-2227.1993.tb12633.x.
5
A bacteriologic basis for the clinical presentations of necrotizing enterocolitis.
J Pediatr Surg. 1980 Aug;15(4):558-64. doi: 10.1016/s0022-3468(80)80773-1.
6
Necrotising enterocolitis after cardiac catheterisation in infants.婴儿心脏导管插入术后的坏死性小肠结肠炎
Arch Dis Child. 1980 Jan;55(1):66-8. doi: 10.1136/adc.55.1.66.
7
Pulsatile aortopulmonary pressure-flow dynamics of patent ductus arteriosus in patients with various hemodynamic states.
Circulation. 1980 Jan;61(1):110-22. doi: 10.1161/01.cir.61.1.110.
8
Necrotizing enterocolitis in the unfed infant.未喂养婴儿的坏死性小肠结肠炎
J Pediatr Surg. 1982 Oct;17(5):620-4. doi: 10.1016/s0022-3468(82)80122-x.
9
Age at onset of necrotizing enterocolitis. Risk factors in small infants.
Am J Dis Child. 1982 Sep;136(9):814-6. doi: 10.1001/archpedi.1982.03970450056013.
10
Necrotizing enterocolitis: a prospective multicenter investigation.坏死性小肠结肠炎：一项前瞻性多中心研究。
Am J Epidemiol. 1980 Jul;112(1):113-23. doi: 10.1093/oxfordjournals.aje.a112960.
Zotero 插件