Sutton R A, Walker V R
Department of Medicine, University of British Columbia, Vancouver, Canada.
Miner Electrolyte Metab. 1994;20(6):352-60.
Enteric hyperoxaluria complicates extensive disease or resection of the small intestine in the presence of an intact colon, and is associated with calcium oxalate nephrolithiasis. In addition to hyperoxaluria these patients have a low urine volume, low urinary ionic strength and hypocitraturia. Many forms of treatment have been recommended, but none has been subjected to a prospective clinical trial. Mild idiopathic hyperoxaluria is reported in 8-50% of idiopathic calcium oxalate stoneformers. Several pathophysiological mechanisms have been proposed, including low dietary calcium and possible oxalate transport defects in the gut and/or the kidney. Mild hyperoxaluria, or a high oxalate:calcium ratio in the urine, may be particularly important risk factors for calcium oxalate stone formation; an approach to the correction of these abnormalities is proposed.
肠道高草酸尿症会使广泛的小肠疾病或小肠切除（结肠完整）复杂化，并与草酸钙肾结石相关。除了高草酸尿症外，这些患者尿量少、尿离子强度低且尿枸橼酸盐减少。已经推荐了多种治疗方法，但尚无一种经过前瞻性临床试验。在8%至50%的特发性草酸钙结石患者中报告有轻度特发性高草酸尿症。已经提出了几种病理生理机制，包括低膳食钙以及肠道和/或肾脏中可能存在的草酸转运缺陷。轻度高草酸尿症或尿中高草酸：钙比值可能是草酸钙结石形成的特别重要的危险因素；本文提出了纠正这些异常情况的方法。
