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[在核糖体中密码子 - 反密码子复合物的立体特异性稳定假说框架内对翻译延伸的稳态动力学分析。II. 存在蛋白质延伸因子和GTP时的动力学方案]

[Analysis of stationary kinetics of translation elongation within the framework of the stereospecific stabilization hypothesis of codon- anticodon complexes in a ribosome. II. Kinetic schemes in the presence of protein elongation factors and GTP].

作者信息

Saĭfullin S R, Potapov A P

出版信息

Mol Biol (Mosk). 1995 Mar-Apr;29(2):434-45.

PMID:7783746
Abstract

Kinetics of the factor-dependent polypeptide elongation is theoretically studied in context of stereospecific stabilization of the codon-anticodon complexes at a ribosome. Kinetic schemes for the different ribosome isomerization stages are examined. The dependence of steady-state elongation rate on elongation factor concentration for each of the schemes is unique, allowing to identify isomerization stages experimentally.

摘要

在核糖体上密码子-反密码子复合物的立体特异性稳定的背景下，从理论上研究了因子依赖性多肽延伸的动力学。研究了不同核糖体异构化阶段的动力学方案。每个方案的稳态延伸速率对延伸因子浓度的依赖性是独特的，这使得能够通过实验识别异构化阶段。

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