慢性乙醇给药的改良液体饮食：通过大鼠乙醇戒断综合征进行验证
A modified liquid diet of chronic ethanol administration: validation by ethanol withdrawal syndrome in rats.
作者信息
Uzbay I T, Kayaalp S O
机构信息
Department of Pharmacology, Faculty of Medicine, Gülhane Military Medical Academy, Ankara, Turkey.
出版信息
Pharmacol Res. 1995 Jan;31(1):37-42. doi: 10.1016/1043-6618(95)80045-x.
The validity of a modified liquid diet prepared from cow's milk, 7.2% ethanol, vitamin A and sucrose mixture has been investigated for chronic ethanol administration in rats. The rats fed by the modified liquid diet lost 3.8% of their body weight along 20 days. The mean ethanol consumption was in the range of 12.6 to 17.6 g kg-1 day-1. The blood ethanol level just before the withdrawal of ethanol was found to be 301.38 +/- 36.68 mg dl-1. A severe ethanol withdrawal syndrome was observed after 20-day exposure to ethanol in the modified liquid diet. The results suggest that the modified liquid diet can be used satisfactorily for chronic ethanol administration in rats.
已对由牛奶、7.2%乙醇、维生素A和蔗糖混合物制备的改良液体饲料用于大鼠慢性乙醇给药的有效性进行了研究。用改良液体饲料喂养的大鼠在20天内体重减轻了3.8%。平均乙醇摄入量在12.6至17.6 g·kg⁻¹·天⁻¹范围内。在停止给予乙醇前，血液乙醇水平为301.38±36.68 mg·dl⁻¹。在经改良液体饲料给予乙醇20天后，观察到严重的乙醇戒断综合征。结果表明，改良液体饲料可令人满意地用于大鼠慢性乙醇给药。
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