Silva Teane M A, Costa Erica A, Paixão Tatiane A, Tsolis Renée M, Santos Renato L
Departamento de Clínica e Cirurgia Veterinária, Escola de Veterinária, Universidade Federal de Minas Gerais, 31270-901 Belo Horizonte, MG, Brazil.
J Biomed Biotechnol. 2011;2011:518323. doi: 10.1155/2011/518323. Epub 2011 Feb 20.
Brucellosis is a chronic infectious disease caused by Brucella spp., a gram-negative facultative intracellular pathogen that affects humans and animals, leading to significant impact on public health and animal industry. Human brucellosis is considered the most prevalent bacterial zoonosis in the world and is characterized by fever, weight loss, depression, hepato/splenomegaly, osteoarticular, and genital infections. Relevant aspects of Brucella pathogenesis have been intensively investigated in culture cells and animal models. The mouse is the animal model more commonly used to study chronic infection caused by Brucella. This model is most frequently used to investigate specific pathogenic factors of Brucella spp., to characterize the host immune response, and to evaluate therapeutics and vaccines. Other animal species have been used as models for brucellosis including rats, guinea pigs, and monkeys. This paper discusses the murine and other laboratory animal models for human and animal brucellosis.
布鲁氏菌病是由布鲁氏菌属引起的一种慢性传染病，布鲁氏菌属是一种革兰氏阴性兼性胞内病原体，可感染人类和动物，对公共卫生和畜牧业造成重大影响。人类布鲁氏菌病被认为是世界上最普遍的细菌性人畜共患病，其特征为发热、体重减轻、抑郁、肝脾肿大、骨关节和生殖器感染。布鲁氏菌发病机制的相关方面已在培养细胞和动物模型中进行了深入研究。小鼠是研究布鲁氏菌引起的慢性感染最常用的动物模型。该模型最常用于研究布鲁氏菌属的特定致病因素、表征宿主免疫反应以及评估治疗方法和疫苗。其他动物物种也已被用作布鲁氏菌病的模型，包括大鼠、豚鼠和猴子。本文讨论了用于人类和动物布鲁氏菌病的小鼠及其他实验动物模型。
