人类胎儿的血清脂质、载脂蛋白和脂蛋白颗粒水平。

Serum lipid, apolipoprotein and lipoparticle levels in the human fetus.

作者信息

Legras B, Durou M R, Ruelland A, Gallou G, Jezequel C, Cloarec L

机构信息

Biochemistry Laboratory, Hôpital Sud, Rennes, France.

出版信息

Prenat Diagn. 1995 Mar;15(3):225-8. doi: 10.1002/pd.1970150305.

DOI:10.1002/pd.1970150305

PMID:7784380

Abstract

Blood collected from 62 fetuses aged 20-38 weeks of gestation was studied. The values of ten lipid parameters were determined: cholesterol (TC), triglycerides (TGs), apolipoprotein A1 (apo A1), apolipoprotein B (apo B), apolipoprotein E (apo E), total apolipoprotein CIII (apo CIII), apolipoprotein CIII present in particles containing apo B (apo CIII LpB) or not (apo CIII Lp non-B), lipoparticles A1 (LpA1), and lipoprotein a (Lp(a)). The results show that, except for apo E, all the studied parameters were present in lower concentrations than in adults and newborns, and that Lp(a) is not detectable at that stage in life.

摘要

对收集自62例妊娠20 - 38周胎儿的血液进行了研究。测定了十种脂质参数的值：胆固醇（TC）、甘油三酯（TGs）、载脂蛋白A1（apo A1）、载脂蛋白B（apo B）、载脂蛋白E（apo E）、总载脂蛋白CIII（apo CIII）、存在于含apo B颗粒中的载脂蛋白CIII（apo CIII LpB）或不存在于含apo B颗粒中的载脂蛋白CIII（apo CIII Lp非B）、脂蛋白A1（LpA1）和脂蛋白a（Lp(a)）。结果表明，除apo E外，所有研究参数的浓度均低于成人和新生儿，且在生命的那个阶段检测不到Lp(a)。