Beaufils P, Slama R
Clinique Cardiologique, Hôpital Lariboisière, Paris.
Presse Med. 1995 Apr 29;24(16):779-82.
Whatever the cause and clinical features, establishing the strategy for the medical treatment of atrial fibrillation, requires three basic steps. First sinus rhythm must be restored, followed by the prescription of antiarrhythmic drugs to prevent recurrence and finally the use of anticoagulants. Obviously the underlying heart disease has a major effect on the patient's tolerance of atrial fibrillation, the risks of peripheral embolism and overall mortality. In patients with "solitary atrial fibrillation" and an apparently normal heart, each step of the treatment must be examined in light of the individual patients clinical situation and the risks of haemorrhage with anticoagulants as well as the risk of lethal ventricular arrhythmia due to the arrhythmogenic effect of class la or 1c antiarrhythmic drugs.
无论病因和临床特征如何,确立心房颤动的药物治疗策略都需要三个基本步骤。首先必须恢复窦性心律,其次是开具抗心律失常药物以预防复发,最后是使用抗凝剂。显然,潜在的心脏病对患者对心房颤动的耐受性、外周栓塞风险和总体死亡率有重大影响。对于“孤立性心房颤动”且心脏明显正常的患者,治疗的每一步都必须根据个体患者的临床情况、抗凝剂引起出血的风险以及由于Ⅰa类或Ⅰc类抗心律失常药物的致心律失常作用导致致命性室性心律失常的风险来进行评估。