Middelkoop H A, Lammers G J, Van Hilten B J, Ruwhof C, Pijl H, Kamphuisen H A
Department of Neurology, Leiden University Hospital, The Netherlands.
Psychophysiology. 1995 May;32(3):286-91. doi: 10.1111/j.1469-8986.1995.tb02957.x.
The circadian distribution of motor activity and immobility of 14 unmedicated narcoleptics and matched controls was evaluated by monitoring continuous wrist motor activity 5 successive days and nights at home. Sleep was also assessed by sleep logs. The amplitude of the circadian rhythm of motor activity and immobility was significantly lower in narcoleptics than in controls. The variables that best distinguish narcoleptics from controls were the diurnal and nocturnal mean duration of uninterrupted immobility, which can be explained by excessive daytime sleepiness and frequent nocturnal awakenings, respectively. Thus, measures of diurnal and nocturnal motor activity and immobility appear useful for the objective assessment of some of the sleep-wakefulness manifestations of narcolepsy.
通过在家连续5个昼夜监测手腕运动活动，评估了14名未用药发作性睡病患者和匹配对照组的运动活动和静止状态的昼夜分布情况。还通过睡眠日志评估了睡眠情况。发作性睡病患者运动活动和静止状态的昼夜节律幅度显著低于对照组。最能区分发作性睡病患者和对照组的变量是日间和夜间不间断静止状态的平均持续时间，分别可由白天过度嗜睡和夜间频繁觉醒解释。因此，日间和夜间运动活动及静止状态的测量方法似乎有助于客观评估发作性睡病的一些睡眠-觉醒表现。
