胸膜胆固醇在鉴别漏出液和渗出液中的作用。一项对232例患者的前瞻性研究。

Pleural cholesterol in differentiating transudates and exudates. A prospective study of 232 cases.

作者信息

Gil Suay V, Martínez Moragón E, Cases Viedma E, Perpiñá Tordera M, León Fábregas M, Sanchis Aldás J

机构信息

Servicio de Neumología, Hospital Universitario La Fe, Valencia, España.

出版信息

Respiration. 1995;62(2):57-63. doi: 10.1159/000196392.

DOI:10.1159/000196392

PMID:7784710

Abstract

Two hundred and four patients with pleural effusion were studied to investigate the utility of Light's criteria and pleural fluid cholesterol level (pCHOL) in the identification of exudative pleural effusion (EPE) and transudative pleural effusion (TPE). There were 48 TPE, 56 tumor, 47 tuberculous, 30 metapneumonic and 23 miscellaneous patients. A value > or = 54 mg/dl for pCHOL and > or = 0.32 for the pleura/serum cholesterol ratio (p/sCHOL) showed sensitivity (S) and specificity (Sp) of 95.5% and 91.6% for pCHOL, and 97.4% and 91.6% for p/sCHOL, respectively. Combined pCHOL and/or p/sCHOL showed a S of 98.7% and Sp of 89.5%. Light's criteria achieved a S of 100% and Sp of 64.5%. Combined pCHOL and p/sCHOL revealed a similar accuracy to Light's criteria in EPE diagnosis but was found to be more exact in TPE diagnosis.

摘要

对204例胸腔积液患者进行研究，以探讨Light标准和胸腔积液胆固醇水平（pCHOL）在鉴别渗出性胸腔积液（EPE）和漏出性胸腔积液（TPE）中的作用。其中有48例TPE患者、56例肿瘤患者、47例结核患者、30例肺炎旁积液患者和23例其他患者。pCHOL值≥54mg/dl以及胸膜/血清胆固醇比值（p/sCHOL）≥0.32时，pCHOL的敏感性（S）和特异性（Sp）分别为95.5%和91.6%，p/sCHOL的敏感性和特异性分别为97.4%和91.6%。联合pCHOL和/或p/sCHOL时，敏感性为98.7%，特异性为89.5%。Light标准的敏感性为100%，特异性为64.5%。联合pCHOL和p/sCHOL在EPE诊断中的准确性与Light标准相似，但在TPE诊断中更为准确。