Traub O, Van Bibber R
Dept. of Physiology and Biophysics, University of Washington School of Medicine, Seattle 98195, USA.
West J Med. 1995 May;162(5):439-45.
Patients with insulin-dependent diabetes mellitus are at high risk for vascular disorders such as hypertension, nephropathy, and retinopathy. The most common cause of morbidity and mortality in patients with insulin-dependent diabetes is vascular disease. Despite ongoing research, the pathogenesis of vascular disease in diabetes remains unclear. In recent years, numerous investigators have examined the role of the endothelium-derived relaxing factor, nitric oxide, in the disease state of hypertension and its complications. We review the role of nitric oxide in the development of diabetes-related vascular disease and discuss findings suggesting that nitric oxide metabolism and vascular responsiveness to nitric oxide are altered in diabetes. Patients with diabetes may benefit from therapy that addresses this pathogenic deficiency.
胰岛素依赖型糖尿病患者患高血压、肾病和视网膜病变等血管疾病的风险很高。胰岛素依赖型糖尿病患者发病和死亡的最常见原因是血管疾病。尽管研究仍在进行，但糖尿病血管疾病的发病机制仍不清楚。近年来，许多研究人员研究了内皮源性舒张因子一氧化氮在高血压疾病状态及其并发症中的作用。我们综述了一氧化氮在糖尿病相关血管疾病发展中的作用，并讨论了表明糖尿病中一氧化氮代谢和血管对一氧化氮的反应性发生改变的研究结果。糖尿病患者可能会从解决这种致病缺陷的治疗中受益。
