[多环胺化合物HH01对大鼠实验性胃溃疡的抗溃疡作用]
[Antiulcer effect of polycyclicamine compound HH01 on experimental gastric ulcer in rats].
作者信息
Zhang S R, Cui G J, Xu R M, Han C, Guo J Y
机构信息
Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing.
出版信息
Yao Xue Xue Bao. 1995;30(2):103-6.
HH01(1-methyl-3,4,5,6,9,10-hexahydro-7H-cyclopenta [j,k]-1,3-dioxolo [4,5-h]-pyrrolo[2,1-b] [3]-benzazepine) A and B in doses 30 mg.kg-1 and 60 mg.kg-1 were shown to protect gastric mucosa of rats from damage induced by absolute ethanol, cold-immersion stress and pylorus ligation. No effect was found in indomethacin model in mice. HH01 was found to decrease secretion of gastric juice and HCl in pylorus ligated rats. The content of DNA in gastric juice of animals treated with HH01 was lower than in control. The results suggest that HH01 is effective as an anti-ulcer agent, but its mechanism of action is yet unknown.
HH01（1-甲基-3,4,5,6,9,10-六氢-7H-环戊并[j,k]-1,3-二氧杂环戊烯并[4,5-h]-吡咯并[2,1-b][3]-苯并氮杂卓）A和B以30毫克/千克和60毫克/千克的剂量给药时，可保护大鼠胃黏膜免受无水乙醇、冷浸应激和幽门结扎诱导的损伤。在小鼠吲哚美辛模型中未发现作用。发现HH01可降低幽门结扎大鼠的胃液和盐酸分泌。用HH01处理的动物胃液中的DNA含量低于对照组。结果表明，HH01作为抗溃疡剂是有效的，但其作用机制尚不清楚。
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