Shine V J, Latha P G, Shyamal S, Suja S R, Anuja G I, Sini S, Pradeep S, Rajasekharan S
Ethnomedicine and Ethnopharmacology Division, Tropical Botanic Garden and Research Institute, Palode, Trivandrum 695 562, India.
J Ethnopharmacol. 2009 Sep 7;125(2):350-5. doi: 10.1016/j.jep.2009.04.039. Epub 2009 May 4.
Cyclea peltata (Lam.) Hook. f. & Thoms. (Menispermaceae), locally called 'Padathaali/Padakizhangu' is used in Ayurvedic medicine to treat peptic ulcer.
To evaluate the gastric antisecretory and antiulcer activity of Cyclea peltata.
The ethanolic extract of Cyclea peltata root was used to evaluate its gastric antisecretory and antiulcer effect in the pylorus-ligated rat model and gastric lesions induced by ethanol or ethanol and indomethacin respectively in rats. The levels of gastric wall mucus, non-protein sulfhydryl groups (NP-SH), malondialdehyde, protein and catalase activity in the stomach samples of Cyclea peltata treated and control groups of rats were also quantified.
The ethanolic extract of Cyclea peltata roots showed significant antisecretory activity as evidenced by decreased pepsin secretion, gastric juice volume and acid output in pylorus-ligated rats. Pretreatment with Cyclea peltata extract provided significant protection against the peptic ulceration caused by ethanol administered individually, or in combination with indomethacin. Our studies also revealed that pretreatment with Cyclea peltata significantly increased the gastric protein and catalase concentration of ethanol treated rats. Further, it showed significant gastroprotective effects on the stomach wall of ethanol or ethanol and indomethacin treated rats by decreasing malondialdehyde level, increasing the gastric wall mucus and non-protein sulfhydryl groups.
The present findings demonstrate that Cyclea peltata ethanolic extract has potent antisecretory and antiulcer effects and justify the traditional/ethnic usage of this herb to treat peptic ulcers and consequent stomach ache.
轮环藤（学名：Cyclea peltata (Lam.) Hook. f. & Thoms.，防己科），当地称为“Padathaali/Padakizhangu”，在阿育吠陀医学中用于治疗消化性溃疡。
评估轮环藤的胃抗分泌和抗溃疡活性。
采用轮环藤根的乙醇提取物，分别在幽门结扎大鼠模型以及大鼠中由乙醇或乙醇与消炎痛诱导的胃损伤模型中，评估其胃抗分泌和抗溃疡作用。同时还对轮环藤处理组和对照组大鼠胃样本中的胃壁黏液、非蛋白巯基（NP-SH）、丙二醛、蛋白质和过氧化氢酶活性水平进行了定量分析。
轮环藤根的乙醇提取物显示出显著的抗分泌活性，这可通过幽门结扎大鼠中胃蛋白酶分泌减少、胃液体积和酸分泌量降低得到证明。用轮环藤提取物预处理可显著保护大鼠免受单独给予乙醇或乙醇与消炎痛联合给药所引起的消化性溃疡。我们的研究还表明，用轮环藤预处理可显著提高乙醇处理大鼠的胃蛋白和过氧化氢酶浓度。此外，通过降低丙二醛水平、增加胃壁黏液和非蛋白巯基，它对乙醇或乙醇与消炎痛处理大鼠的胃壁显示出显著的胃保护作用。
目前的研究结果表明，轮环藤乙醇提取物具有强大的抗分泌和抗溃疡作用，证明了该草药在治疗消化性溃疡及随之而来的胃痛方面的传统/民族用药合理性。
