Archunan G, Aruldhas M M, Govindarajulu P
Department of Endocrinology, University of Madras, Taramani, India.
Acta Physiol Hung. 1994;82(4):377-81.
The effect of food deprivation on the rate of pregnancy failure in newly inseminated mice was evaluated. The pre-implantation fasting for 48 h beginning on day 4 or 5 postcoitum induced a high rate of pregnancy failure in newly inseminated females. However, fasting for 48 h on day 6 had a moderate effect in inducing pregnancy failure. By contrast, females which were deprived of food on day 7 postcoitum exhibited a significant reduction in the rate of pregnancy failure. Pre-implantation fasting was highly effective in inducing pregnancy failure compared to that of post-implantation fasting. The results suggest that fasting (i.e. day 4 or 5 postcoitum)--induced depression in prolactin has resulted in failure of pregnancy and fasting at post-implantation period (i.e. day 6 or after postcoitum) has not been interfered with progesterone production by placenta.
评估了食物剥夺对新受精小鼠妊娠失败率的影响。在交配后第4天或第5天开始进行48小时的植入前禁食，会导致新受精雌性小鼠出现高妊娠失败率。然而，在第6天禁食48小时对诱导妊娠失败有中等程度的影响。相比之下，在交配后第7天被剥夺食物的雌性小鼠妊娠失败率显著降低。与植入后禁食相比，植入前禁食在诱导妊娠失败方面非常有效。结果表明，禁食（即交配后第4天或第5天）诱导的催乳素降低导致了妊娠失败，而植入后期（即交配后第6天或之后）的禁食并未干扰胎盘的孕酮产生。
