Hans S, Laccourreye O, Jouffre V, Menard M, Brasnu D, Laccourreye H
Service d'Otorhinolaryngologie et de chirurgie Cervico-faciale, Hôpital Laënnec, U.F.R. Necker Enfants Malades, Université Paris V.
Ann Otolaryngol Chir Cervicofac. 1994;111(6):337-41.
Seven cases of malignant inverting papillomas are presented (6 men and 1 woman) with ages ranging from 31 to 72 years (mean age: 58 years); the minimum follow up was 37 months. The diagnosis was based on the histopathologic analysis of biopsy in five patients. In two patients the diagnosis was confirmed by the pathological analysis of the specimen. Treatment was always surgical: lateral rhinotomy and total ethmoidectomy. Neoadjuvant chemotherapy was given to four patients. Post operative radiation therapy was delivered in five patients. Five patients on seven died: local recurrence and systemic metastases: 3; systemic metastases: 1; second primary: 1. Reports from the literature are discussed. The authors emphasize the treatment modalities based on complete tumor removal through lateral rhinotomy.
本文报告了7例恶性内翻性乳头状瘤患者（6例男性，1例女性），年龄在31至72岁之间（平均年龄：58岁）；最短随访时间为37个月。5例患者的诊断基于活检的组织病理学分析。2例患者的诊断通过标本的病理分析得以证实。治疗均采用手术方式：鼻侧切开术和全筛窦切除术。4例患者接受了新辅助化疗。5例患者接受了术后放射治疗。7例患者中有5例死亡：局部复发和全身转移：3例；全身转移：1例；第二原发肿瘤：1例。文中讨论了来自文献的报道。作者强调基于通过鼻侧切开术完全切除肿瘤的治疗方式。
