Lesperance M M, Esclamado R M
Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, USA.
Laryngoscope. 1995 Feb;105(2):178-83. doi: 10.1288/00005537-199502000-00013.
A retrospective review of all cases of inverted papilloma at the University of Michigan from 1975 to 1992 revealed 51 cases of inverted papilloma. Of these, 14 (27%) had an associated squamous cell carcinoma (SCC). Eight (16%) were metachronous and 6 (11%) were synchronous. At a mean follow-up of 53 months, the disease-free survival of patients with carcinoma limited to the nasal cavity and paranasal sinuses was 57% (4/7) compared to 14% (1/7) of those patients presenting with disease extending beyond the nasal cavity and paranasal sinuses. The data also support the lateral rhinotomy approach with medial maxillectomy and ethmoidectomy as a minimum procedure followed by postoperative radiation therapy. The mean interval between the diagnosis of inverted papilloma and development of SCC was 63 months (range, 6 months to 13 years). Therefore, long-term follow-up with clinical examination and computed tomography (CT) scan is indicated for all patients with inverted papilloma.
对密歇根大学1975年至1992年所有内翻性乳头状瘤病例进行的回顾性研究显示，共有51例内翻性乳头状瘤。其中，14例（27%）伴有鳞状细胞癌（SCC）。8例（16%）为异时性，6例（11%）为同时性。平均随访53个月时，局限于鼻腔和鼻窦的癌患者无病生存率为57%（4/7），而疾病超出鼻腔和鼻窦的患者无病生存率为14%（1/7）。数据还支持采用外侧鼻切开术联合内侧上颌骨切除术和筛窦切除术作为最低限度的手术，术后进行放射治疗。内翻性乳头状瘤诊断与SCC发生之间的平均间隔为63个月（范围为6个月至13年）。因此，所有内翻性乳头状瘤患者均需进行长期临床检查和计算机断层扫描（CT）随访。
